Forsythiaside | CAS#79916-77-1 | glycoside

MedKoo Cat#: 146354 | Name: Forsythiaside

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Forsythiaside is a phenylethanoid glycoside isolated from the fruit of Forsythia suspensa, a plant used in traditional Chinese medicine. It exhibits potent anti-inflammatory, antioxidant, and antimicrobial properties. Forsythiaside works by inhibiting pro-inflammatory cytokines and oxidative stress pathways, particularly through modulation of NF-κB and MAPK signaling.

Chemical Structure

Forsythiaside

CAS#79916-77-1

Theoretical Analysis

MedKoo Cat#: 146354

Name: Forsythiaside

CAS#: 79916-77-1

Chemical Formula: C29H36O15

Exact Mass: 624.2054

Molecular Weight: 624.59

Elemental Analysis: C, 55.77; H, 5.81; O, 38.42

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Forsythiaside;

IUPAC/Chemical Name

(2R,3S,4R,5R,6R)-6-(3,4-dihydroxyphenethoxy)-4,5-dihydroxy-2-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-3-yl (E)-3-(3,4-dihydroxyphenyl)acrylate

InChi Key

DTOUWTJYUCZJQD-UJERWXFOSA-N

InChi Code

1S/C29H36O15/c1-13-22(35)23(36)25(38)29(42-13)41-12-20-27(44-21(34)7-4-14-2-5-16(30)18(32)10-14)24(37)26(39)28(43-20)40-9-8-15-3-6-17(31)19(33)11-15/h2-7,10-11,13,20,22-33,35-39H,8-9,12H2,1H3/b7-4+/t13-,20+,22-,23+,24+,25+,26+,27+,28+,29+/m0/s1

SMILES Code

C[C@@H]1O[C@@H](OC[C@H]2O[C@@H](OCCC3=CC=C(O)C(O)=C3)[C@H](O)[C@@H](O)[C@@H]2OC(=O)\C=C\C4=CC(O)=C(O)C=C4)[C@H](O)[C@H](O)[C@H]1O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 624.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Wang J, Xue X, Zhao X, Luo L, Liu J, Dai S, Zhang F, Wu R, Liu Y, Peng C, Li Y. Forsythiaside A alleviates acute lung injury by inhibiting inflammation and epithelial barrier damages in lung and colon through PPAR-γ/RXR-α complex. J Adv Res. 2024 Jun;60:183-200. doi: 10.1016/j.jare.2023.08.006. Epub 2023 Aug 12. PMID: 37579917; PMCID: PMC11156707. 2: Liu J, Gao Y, Zhang H, Hao Z, Zhou G, Wen H, Su Q, Tong C, Yang X, Wang X. Forsythiaside A attenuates mastitis via PINK1/Parkin-mediated mitophagy. Phytomedicine. 2024 Mar;125:155358. doi: 10.1016/j.phymed.2024.155358. Epub 2024 Jan 12. PMID: 38241916. 3: Gong L, Wang C, Zhou H, Ma C, Zhang Y, Peng C, Li Y. A review of pharmacological and pharmacokinetic properties of Forsythiaside A. Pharmacol Res. 2021 Jul;169:105690. doi: 10.1016/j.phrs.2021.105690. Epub 2021 May 23. PMID: 34029711. 4: Gong L, Zhou H, Zhang S, Wang C, Fu K, Ma C, Zhang Y, Peng C, Li Y. CD44-Targeting Drug Delivery System of Exosomes Loading Forsythiaside A Combats Liver Fibrosis via Regulating NLRP3-Mediated Pyroptosis. Adv Healthc Mater. 2023 Apr;12(11):e2202228. doi: 10.1002/adhm.202202228. Epub 2023 Jan 15. PMID: 36603210. 5: Kim YE, Bak SB, Kim MJ, Bae SJ, Lee WY, Kim YW. Forsythiaside A Activates AMP-Activated Protein Kinase and Regulates Oxidative Stress via Nrf2 Signaling. Int J Mol Sci. 2023 Dec 1;24(23):17033. doi: 10.3390/ijms242317033. PMID: 38069356; PMCID: PMC10707188. 6: Guo Q, Wu Z, Wang K, Shi J, Wei M, Lu B, Huang Z, Ji L. Forsythiaside-A improved bile-duct-ligation-induced liver fibrosis in mice: The involvement of alleviating mitochondrial damage and ferroptosis in hepatocytes via activating Nrf2. Free Radic Biol Med. 2024 Sep;222:27-40. doi: 10.1016/j.freeradbiomed.2024.05.042. Epub 2024 May 28. PMID: 38815774. 7: Wang C, Chen S, Guo H, Jiang H, Liu H, Fu H, Wang D. Forsythoside A Mitigates Alzheimer's-like Pathology by Inhibiting Ferroptosis-mediated Neuroinflammation via Nrf2/GPX4 Axis Activation. Int J Biol Sci. 2022 Feb 28;18(5):2075-2090. doi: 10.7150/ijbs.69714. PMID: 35342364; PMCID: PMC8935224. 8: Sun J, Zhu J, Chen L, Duan B, Wang R, Zhang M, Xu J, Liu W, Xu Y, Feng F, Qu W. Forsythiaside B inhibits myocardial fibrosis via down regulating TGF-β1/Smad signaling pathway. Eur J Pharmacol. 2021 Oct 5;908:174354. doi: 10.1016/j.ejphar.2021.174354. Epub 2021 Jul 17. PMID: 34284013. 9: Tuoheti K, Bai X, Yang L, Wang X, Cao Y, Yisha Z, Guo L, Zhan S, Wu Z, Liu T. Forsythiaside A suppresses renal fibrosis and partial epithelial-mesenchymal transition by targeting THBS1 through the PI3K/AKT signaling pathway. Int Immunopharmacol. 2024 Mar 10;129:111650. doi: 10.1016/j.intimp.2024.111650. Epub 2024 Feb 10. PMID: 38342062. 10: Wang J, Xin L, Wang H, Xu L, Zhao F, Li W, Yang Y, Wang W, Shan L. Forsythiaside A alleviates acute lung injury via the RNF99/TRAF6/NF-κB signaling pathway. Int Immunopharmacol. 2024 Oct 25;140:112814. doi: 10.1016/j.intimp.2024.112814. Epub 2024 Aug 1. PMID: 39094364. 11: Yang Z, Ning X, Zhang Y. Forsythiaside Protected H9c2 Cardiomyocytes from H2O2-Induced Oxidative Stress and Apoptosis via Activating Nrf2/HO-1 Signaling Pathway. Int Heart J. 2022;63(5):904-914. doi: 10.1536/ihj.21-585. PMID: 36184550. 12: Yang F, Zhang Q, Wang X, Hu Y, Chen S. Forsythiaside A ameliorates bleomycin-induced pulmonary fibrosis by inhibiting oxidative stress and apoptosis. Immun Inflamm Dis. 2024 Aug;12(8):e70006. doi: 10.1002/iid3.70006. PMID: 39172055; PMCID: PMC11340632. 13: Chen L, Yan Y, Chen T, Zhang L, Gao X, Du C, Du H. Forsythiaside prevents β-amyloid-induced hippocampal slice injury by upregulating 2-arachidonoylglycerol via cannabinoid receptor 1-dependent NF-κB pathway. Neurochem Int. 2019 May;125:57-66. doi: 10.1016/j.neuint.2019.02.008. Epub 2019 Feb 13. PMID: 30769029. 14: Zheng X, Chen Z, Shi S, Yan H, Zhou J, Jiang L, Wang H, Hou G, Jiang Z. Forsythiaside A improves Influenza A virus infection through TLR7 signaling pathway in the lungs of mice. BMC Complement Med Ther. 2022 Jun 22;22(1):164. doi: 10.1186/s12906-022-03644-8. PMID: 35733131; PMCID: PMC9214192. 15: Tian JC, Zhang XL, Cui JR, Li XG. Impact of Azithromycin on Forsythiaside Pharmacokinetics in Rats: A Population Modeling Method. Curr Med Sci. 2022 Aug;42(4):863-870. doi: 10.1007/s11596-022-2596-2. Epub 2022 Jun 8. PMID: 35678908; PMCID: PMC9178217. 16: Lu C, Zheng SF, Liu J. Forsythiaside A alleviates renal damage in adriamycin-induced nephropathy. Front Biosci (Landmark Ed). 2020 Jan 1;25(3):526-535. doi: 10.2741/4818. PMID: 31585901. 17: Tong C, Chen T, Chen Z, Wang H, Wang X, Liu F, Dai H, Wang X, Li X. Forsythiaside a plays an anti-inflammatory role in LPS-induced mastitis in a mouse model by modulating the MAPK and NF-κB signaling pathways. Res Vet Sci. 2021 May;136:390-395. doi: 10.1016/j.rvsc.2021.03.020. Epub 2021 Mar 24. PMID: 33799169. 18: Gao Y, Hao Z, Zhang H, Liu J, Zhou G, Wen H, Su Q, Tong C, Huang S, Wang X. Forsythiaside A attenuates lipopolysaccharide-induced mouse mastitis by activating autophagy and regulating gut microbiota and metabolism. Chem Biol Interact. 2024 Jun 1;396:111044. doi: 10.1016/j.cbi.2024.111044. Epub 2024 May 9. PMID: 38729284. 19: Xu C, Miao H, Chen X, Zhang H. Cellular mechanism of action of forsythiaside for the treatment of diabetic kidney disease. Front Pharmacol. 2023 Jan 13;13:1096536. doi: 10.3389/fphar.2022.1096536. PMID: 36712665; PMCID: PMC9880420. 20: Chen X, Wang K, Chu D, Zhu Y, Zhang W, Cao H, Xie W, Lu C, Li X. [Forsythiaside B inhibits cerebral ischemia/reperfusion-induced oxidative stress injury in mice via the AMPK/DAF-16/FOXO3 pathway]. Nan Fang Yi Ke Da Xue Xue Bao. 2023 Feb 20;43(2):199-205. Chinese. doi: 10.12122/j.issn.1673-4254.2023.02.06. PMID: 36946038; PMCID: PMC10034537.