Ostruthol | CAS#642-08-0 | coumarin

MedKoo Cat#: 146187 | Name: Ostruthol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ostruthol is a natural coumarin derivative primarily isolated from the roots of Peucedanum ostruthium (masterwort). It exhibits various biological activities, including anti-inflammatory, anticancer, and antimicrobial effects. Ostruthol's mechanism involves modulation of signaling pathways such as NF-κB and MAPK, contributing to reduced inflammation and inhibited tumor cell proliferation. Due to these properties, it is being explored for therapeutic potential in conditions like cancer and chronic inflammation.

Chemical Structure

Ostruthol

CAS#642-08-0

Theoretical Analysis

MedKoo Cat#: 146187

Name: Ostruthol

CAS#: 642-08-0

Chemical Formula: C21H22O7

Exact Mass: 386.1366

Molecular Weight: 386.40

Elemental Analysis: C, 65.28; H, 5.74; O, 28.98

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Ostruthol;

IUPAC/Chemical Name

(R)-3-hydroxy-3-methyl-1-((7-oxo-7H-furo[3,2-g]chromen-4-yl)oxy)butan-2-yl (Z)-2-methylbut-2-enoate

InChi Key

WXULKGXQMWVWMP-OMLDUKLJSA-N

InChi Code

1S/C21H22O7/c1-5-12(2)20(23)28-17(21(3,4)24)11-26-19-13-6-7-18(22)27-16(13)10-15-14(19)8-9-25-15/h5-10,17,24H,11H2,1-4H3/b12-5-/t17-/m1/s1

SMILES Code

C\C=C(\C)C(=O)O[C@H](COC1=C2C=COC2=CC3=C1C=CC(=O)O3)C(C)(C)O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 386.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Vogl S, Zehl M, Picker P, Urban E, Wawrosch C, Reznicek G, Saukel J, Kopp B. Identification and quantification of coumarins in Peucedanum ostruthium (L.) Koch by HPLC-DAD and HPLC-DAD-MS. J Agric Food Chem. 2011 May 11;59(9):4371-7. doi: 10.1021/jf104772x. Epub 2011 Mar 22. PMID: 21425828. 2: Zwirchmayr J, Grienke U, Hummelbrunner S, Seigner J, de Martin R, Dirsch VM, Rollinger JM. A Biochemometric Approach for the Identification of In Vitro Anti- Inflammatory Constituents in Masterwort. Biomolecules. 2020 Apr 28;10(5):679. doi: 10.3390/biom10050679. PMID: 32354017; PMCID: PMC7277629. 3: Sarkhail P. Traditional uses, phytochemistry and pharmacological properties of the genus Peucedanum: a review. J Ethnopharmacol. 2014 Oct 28;156:235-70. doi: 10.1016/j.jep.2014.08.034. Epub 2014 Sep 3. PMID: 25193684. 4: Vuorela H, Dallenbach-Tölke K, Nyiredy S, Hiltunen R, Sticher O. HPLC Analysis of the Main Furanocoumarins from Peucedanum palustre. Planta Med. 1989 Apr;55(2):181-4. doi: 10.1055/s-2006-961919. PMID: 17262336.