Physalaemin | NK1 receptor | CAS#4705-64-0

MedKoo Cat#: 128912 | Name: Physalaemin TFA

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Physalaemin is a peptide antagonist of the neurokinin-1 (NK1) receptor (Ki = 1.51 nM).

Chemical Structure

Physalaemin TFA

CAS#4705-64-0

Theoretical Analysis

MedKoo Cat#: 128912

Name: Physalaemin TFA

CAS#: 4705-64-0

Chemical Formula: C60H85F3N14O18S

Exact Mass: 1378.5839

Molecular Weight: 1379.48

Elemental Analysis: C, 52.24; H, 6.21; F, 4.13; N, 14.22; O, 20.88; S, 2.32

Price and Availability

Size	Price	Availability
1mg	USD 350.00	2 Weeks
5mg	USD 650.00	2 Weeks
10mg	USD 1,250.00	2 Weeks

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Related CAS #

No Data

Synonym

Physalaemin TFA; Physalaemin;

IUPAC/Chemical Name

(S)-4-((S)-2-(((5S,8S,14S,17S,20S,23S)-25-amino-20-(4-aminobutyl)-17-benzyl-5-carbamoyl-14-(4-hydroxybenzyl)-8-isobutyl-7,10,13,16,19,22,25-heptaoxo-2-thia-6,9,12,15,18,21-hexaazapentacosan-23-yl)carbamoyl)pyrrolidin-1-yl)-4-oxo-3-((S)-2-((S)-5-oxopyrrolidine-2-carboxamido)propanamido)butanoic acid--2,2,2-trifluoroacetic acid (1/1)

InChi Key

DDNSQNUDDOKWMI-FKIDJSLMSA-N

InChi Code

InChI=1S/C58H84N14O16S.C2HF3O2/c1-31(2)25-39(54(84)66-36(49(61)79)21-24-89-4)65-47(76)30-62-51(81)40(27-34-15-17-35(73)18-16-34)68-55(85)41(26-33-11-6-5-7-12-33)69-53(83)37(13-8-9-22-59)67-56(86)42(28-45(60)74)70-57(87)44-14-10-23-72(44)58(88)43(29-48(77)78)71-50(80)32(3)63-52(82)38-19-20-46(75)64-38;3-2(4,5)1(6)7/h5-7,11-12,15-18,31-32,36-44,73H,8-10,13-14,19-30,59H2,1-4H3,(H2,60,74)(H2,61,79)(H,62,81)(H,63,82)(H,64,75)(H,65,76)(H,66,84)(H,67,86)(H,68,85)(H,69,83)(H,70,87)(H,71,80)(H,77,78);(H,6,7)/t32-,36-,37-,38-,39-,40-,41-,42-,43-,44-;/m0./s1

SMILES Code

NC(C[C@H](NC([C@H]1N(C([C@@H](NC([C@H](C)NC([C@@H]2CCC(N2)=O)=O)=O)CC(O)=O)=O)CCC1)=O)C(N[C@H](C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CC4=CC=C(O)C=C4)C(NCC(N[C@H](C(N[C@@H](CCSC)C(N)=O)=O)CC(C)C)=O)=O)=O)=O)CCCCN)=O)=O.OC(C(F)(F)F)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,379.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Antoniou, M., and Poulos, C. Analogues of the C-terminal fragments of neurokinins with modifications at their C-terminal methionyl residue. Structure-activity studies. Int. J. Pept. Protein Res. 43(4), 344-350 (1994). 2. Zhao, X., Valantas, J.A., Vyas, S., et al. Comparative toxicity of amyloid β-peptide in neuroblastoma cell lines: Effects of albumin and physalaemin. Comp. Biochem. Physiol. C Comp. Pharmacol. Toxicol. 106(1), 165-170 (1993). 3. Leander, S., Håkanson, R., Rosell, S., et al. A specific substance P antagonist blocks smooth muscle contractions induced by non-cholinergic, non-adrenergic nerve stimulation. Nature 294(5840), 467-469 (1981). 4. Bertaccini, G., and De Caro, G. The effect of physalaemin and related polypeptides on salivary secretion. J. Physiol. 181(1), 68-81 (1965).