MedKoo Cat#: 128905 | Name: VU0810464
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

VU0810464 is an activator of G protein-activated inward rectifier potassium channels (GIRKs), also known as Kir3.

Chemical Structure

VU0810464
VU0810464
CAS#2126040-21-7

Theoretical Analysis

MedKoo Cat#: 128905

Name: VU0810464

CAS#: 2126040-21-7

Chemical Formula: C18H21ClFN3O

Exact Mass: 349.1357

Molecular Weight: 349.83

Elemental Analysis: C, 61.80; H, 6.05; Cl, 10.13; F, 5.43; N, 12.01; O, 4.57

Price and Availability

Size Price Availability Quantity
1mg USD 250.00 2 Weeks
5mg USD 550.00 2 Weeks
10mg USD 850.00 2 Weeks
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Related CAS #
No Data
Synonym
VU0810464; VU-0810464; VU 0810464
IUPAC/Chemical Name
2-(3-chloro-4-fluorophenyl)-N-(1-cyclohexyl-3-methyl-1H-pyrazol-5-yl)acetamide
InChi Key
HNJJARDABGKWSO-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H21ClFN3O/c1-12-9-17(23(22-12)14-5-3-2-4-6-14)21-18(24)11-13-7-8-16(20)15(19)10-13/h7-10,14H,2-6,11H2,1H3,(H,21,24)
SMILES Code
ClC1=CC(CC(NC2=CC(C)=NN2C3CCCCC3)=O)=CC=C1F
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 349.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Wieting, J.M., Vadukoot, A.K., Sharma, S., et al. Discovery and Characterization of 1H-Pyrazol-5-yl-2-phenylacetamides as Novel, Non-Urea-Containing GIRK1/2 Potassium Channel Activators. ACS Chem. Neurosci. 8(9), 1873-1879 (2017). 2. Vo, B.N., Abney, K.K., Anderson, A., et al. VU0810464, a non-urea G protein-gated inwardly rectifying K+ (Kir3/GIRK) channel activator, exhibits enhanced selectivity for neuronal Kir3 channels and reduces stress-induced hyperthermia in mice. Br. J. Pharmacol. 176(13), 2238-2249 (2019).