VU533 | CAS#923417-09-8 | NAPE-PLD activator

MedKoo Cat#: 124853 | Name: VU533

Description:

WARNING: This product is for research use only, not for human or veterinary use.

VU533 is a potent NAPE-PLD activator with an EC50 value of 0.30 µM. VU533 activates NAPE-PLD by enhancing its enzymatic activity. This results in increased levels of N-acylethanolamines (NAEs) in cells, particularly anandamide. The IC50 values for the activation of NAPE-PLD were in the low micromolar range (around 2-5 μM), indicating its potency in vitro.

Chemical Structure

VU533

CAS#923417-09-8

Theoretical Analysis

MedKoo Cat#: 124853

Name: VU533

CAS#: 923417-09-8

Chemical Formula: C21H22FN3O3S2

Exact Mass: 447.1087

Molecular Weight: 447.54

Elemental Analysis: C, 56.36; H, 4.96; F, 4.25; N, 9.39; O, 10.72; S, 14.33

Price and Availability

Size	Price	Availability
100mg	USD 950.00	2 Weeks
200mg	USD 1,650.00	2 Weeks
500mg	USD 2,650.00	2 Weeks
1g	USD 3,950.00	2 Weeks
2g	USD 6,850.00	2 Weeks

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Related CAS #

No Data

Synonym

VU533; VU 533; VU-533

IUPAC/Chemical Name

N-(4,7-dimethylbenzo[d]thiazol-2-yl)-1-((4-fluorophenyl)sulfonyl)piperidine-4-carboxamide

InChi Key

UKXHDJBIBJBTIU-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H22FN3O3S2/c1-13-3-4-14(2)19-18(13)23-21(29-19)24-20(26)15-9-11-25(12-10-15)30(27,28)17-7-5-16(22)6-8-17/h3-8,15H,9-12H2,1-2H3,(H,23,24,26)

SMILES Code

CC1=C2SC(NC(C3CCN(S(=O)(C4=CC=C(C=C4)F)=O)CC3)=O)=NC2=C(C)C=C1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 447.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zarrow JE, Alli-Oluwafuyi AM, Youwakim CM, Kim K, Jenkins AN, Suero IC, Jones MR, Mashhadi Z, Mackie K, Waterson AG, Doran AC, Sulikowski GA, Davies SS. Small Molecule Activation of NAPE-PLD Enhances Efferocytosis by Macrophages. ACS Chem Biol. 2023 Aug 18;18(8):1891-1904. doi: 10.1021/acschembio.3c00401. Epub 2023 Aug 2. PMID: 37531659; PMCID: PMC10443532. 2: Zarrow JE, Alli-Oluwafuyi AM, Youwakim CM, Kim K, Jenkins AN, Suero IC, Jones MR, Mashhadi Z, Mackie KP, Waterson AG, Doran AC, Sulikowski GA, Davies SS. Small Molecule Activation of NAPE-PLD Enhances Efferocytosis by Macrophages. bioRxiv [Preprint]. 2023 Feb 28:2023.01.25.525554. doi: 10.1101/2023.01.25.525554. Update in: ACS Chem Biol. 2023 Aug 18;18(8):1891-1904. doi: 10.1021/acschembio.3c00401. PMID: 36747693; PMCID: PMC9900783.