IHMT-337 | EZH2 inhibitor

MedKoo Cat#: 128902 | Name: IHMT-337

Description:

WARNING: This product is for research use only, not for human or veterinary use.

IHMT-337 is a EZH2 inhibitor.

Chemical Structure

IHMT-337

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128902

Name: IHMT-337

CAS#: N/A

Chemical Formula: C31H33ClN4O4

Exact Mass: 560.2190

Molecular Weight: 561.08

Elemental Analysis: C, 66.36; H, 5.93; Cl, 6.32; N, 9.99; O, 11.41

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

CPI-0209 CPI0209; CPI 0209

IUPAC/Chemical Name

2'-acrylamido-4'-chloro-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(N-ethylcyclopropanecarboxamido)-4-methyl-[1,1'-biphenyl]-3-carboxamide

InChi Key

GIPHHPDJSWAKGF-UHFFFAOYSA-N

InChi Code

InChI=1S/C31H33ClN4O4/c1-6-28(37)35-26-15-22(32)10-11-23(26)21-13-24(19(5)27(14-21)36(7-2)31(40)20-8-9-20)29(38)33-16-25-17(3)12-18(4)34-30(25)39/h6,10-15,20H,1,7-9,16H2,2-5H3,(H,33,38)(H,34,39)(H,35,37)

SMILES Code

ClC1=CC(NC(C=C)=O)=C(C2=CC(N(CC)C(C3CC3)=O)=C(C)C(C(NCC4=C(C)C=C(C)NC4=O)=O)=C2)C=C1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 561.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zhang H, Wang Z, Qiao X, Peng N, Wu J, Chen Y, Cheng C. Unveiling the therapeutic potential of IHMT-337 in glioma treatment: targeting the EZH2-SLC12A5 axis. Mol Med. 2024 Jun 17;30(1):91. doi: 10.1186/s10020-024-00857-0. PMID: 38886655; PMCID: PMC11184773. 2: Mei H, Wu H, Yang J, Zhou B, Wang A, Hu C, Qi S, Jiang Z, Zou F, Wang B, Liu F, Chen Y, Wang W, Liu J, Liu Q. Discovery of IHMT-337 as a potent irreversible EZH2 inhibitor targeting CDK4 transcription for malignancies. Signal Transduct Target Ther. 2023 Jan 16;8(1):18. doi: 10.1038/s41392-022-01240-3. PMID: 36642705; PMCID: PMC9841011.