Synonym
Histamine trifluromethyl toluidine, HTMT
IUPAC/Chemical Name
6-((2-(1H-imidazol-5-yl)ethyl)amino)-N-(4-(trifluoromethyl)phenyl)heptanamide dimaleate
InChi Key
ODAOZWTYNWZSBY-SPIKMXEPSA-N
InChi Code
InChI=1S/C19H25F3N4O.2C4H4O4/c1-14(24-11-10-17-12-23-13-25-17)4-2-3-5-18(27)26-16-8-6-15(7-9-16)19(20,21)22;2*5-3(6)1-2-4(7)8/h6-9,12-14,24H,2-5,10-11H2,1H3,(H,23,25)(H,26,27);2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-
SMILES Code
CC(NCCC1=CN=CN1)CCCCC(NC2=CC=C(C(F)(F)F)C=C2)=O.O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
498.50
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Shayo, C., Fernandez, N., Legnazzi, B.L., et al. Histamine H2 receptor desensitization: Involvement of a select array of G protein-coupled receptor kinases. Mol. Pharmacol. 60(5), 1049-1056 (2001).
2. Zhu, Y., Michalovich, D., Wu, H., et al. Cloning, expression, and pharmacological characterization of a novel human histamine receptor. Mol. Pharmacol. 59(3), 434-441 (2001).
3. Qiu, R., Melmon, K.L., and Kahn, M.M. Effects of histamine-trifluoromethyl-toluidide derivative (HTMT) on intracellular calcium in human lymphocytes. J. Pharmacol. Exp. Ther. 253(3), 1245-1252 (1990).
4. Francis, H., Glaser, S., Demorrow, S., et al. Small mouse cholangiocytes proliferate in response to H1 histamine receptor stimulation by activation of the IP3/CaMK I/CREB pathway. Am. J. Physiol. Cell Physiol. 295(2), C499-C513 (2008).
5. Tripathi, T., Shahid, M., Khan, H.M., et al. Modulation of in vivo immunoglobulin production by endogenous histamine and H1R and H2R agonists and antagonists. Pharmacol. Rep. 62(5), 917-925 (2010).
6. Bell, J.K., McQueen, D.S., and Rees, J.L. Involvement of histamine H4 and H1 receptors in scratching induced by histamine receptor agonists in BalbC mice. Br. J. Pharmacol. 142(2), 374-380 (2004).
