ZH8965 is a TAAR1 Agonist. ZH8965 with excellent Gs/Gq activation potency. Subsequent molecular modeling studies explained its unique mechanism of action. Oral treatment with ZH8965significantly alleviated the antipsychotic-like phenotypes and cognitive impairment without inducing catalepsy like haloperidol in the MK-801-induced mice. Moreover, ZH8965 demonstrated favorable PK and safety profiles.
MedKoo Cat#: 128901
Name: ZH8965
CAS#: N/A
Chemical Formula: C12H19ClN2O3S
Exact Mass: 0.0000
Molecular Weight: 306.81
Elemental Analysis: C, 46.98; H, 6.24; Cl, 11.55; N, 9.13; O, 15.64; S, 10.45
The following data is based on the product molecular weight 306.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
