MedKoo Cat#: 128877 | Name: TCL065
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TCL065 is an ionizable cationic lipid (pKa = 6.3) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA and single-guide RNA (sgRNA) in vitro and in vivo.

Chemical Structure

TCL065
TCL065
CAS#1872269-57-2

Theoretical Analysis

MedKoo Cat#: 128877

Name: TCL065

CAS#: 1872269-57-2

Chemical Formula: C51H97NO8

Exact Mass: 851.7214

Molecular Weight: 852.34

Elemental Analysis: C, 71.87; H, 11.47; N, 1.64; O, 15.02

Price and Availability

Size Price Availability Quantity
1mg USD 350.00 2 Weeks
5mg USD 750.00 2 Weeks
10mg USD 1,150.00 2 Weeks
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Related CAS #
No Data
Synonym
TCL065; TCL-065; TCL 065
IUPAC/Chemical Name
2-(((5-(dimethylamino)pentanoyl)oxy)methyl)-2-(((3-pentyloctanoyl)oxy)methyl)propane-1,3-diyl bis(3-pentyloctanoate)
InChi Key
IRCNKFFTLQSCTC-UHFFFAOYSA-N
InChi Code
InChI=1S/C51H97NO8/c1-9-15-21-29-44(30-22-16-10-2)37-48(54)58-41-51(40-57-47(53)35-27-28-36-52(7)8,42-59-49(55)38-45(31-23-17-11-3)32-24-18-12-4)43-60-50(56)39-46(33-25-19-13-5)34-26-20-14-6/h44-46H,9-43H2,1-8H3
SMILES Code
O=C(CCCCN(C)C)OCC(COC(CC(CCCCC)CCCCC)=O)(COC(CC(CCCCC)CCCCC)=O)COC(CC(CCCCC)CCCCC)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 852.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Kenjo, E., Hozumi, H., Makita, Y., et al. Low immunogenicity of LNP allows repeated administrations of CRISPR-Cas9 mRNA into skeletal muscle in mice. Nat. Commun. 12(1), 7101 (2021).