L-002 is an inhibitor of p300 histone acyltransferase (KAT3B). L-002 also inhibits acetylation of histones and p53 and suppresses STAT3 activation. In vivo, L-002 potently suppressed tumor growth of TNBC cell line MDA-MB-468 xenografts.
MedKoo Cat#: 574767
Name: L-002
CAS#: 321695-57-2
Chemical Formula: C15H15NO5S
Exact Mass: 321.0671
Molecular Weight: 321.35
Elemental Analysis: C, 56.07; H, 4.71; N, 4.36; O, 24.89; S, 9.98
| Solvent | mg/mL | mM | comments | |
|---|---|---|---|---|
| Solubility | ||||
| DMF | 30.0 | 93.36 | ||
| DMSO | 52.2 | 162.34 | ||
| DMSO:PBS (pH 7.2) (1:2) | 0.3 | 0.78 | ||
| Ethanol | 2.5 | 7.78 |
The following data is based on the product molecular weight 321.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
