T-226296 | CAS#331758-35-1 | MCHR1 Antagonist

MedKoo Cat#: 532805 | Name: T-226296

Description:

WARNING: This product is for research use only, not for human or veterinary use.

T-226296 is a melanin concentrating hormone receptor 1 (MCHR1) antagonist.

Chemical Structure

T-226296

CAS#331758-35-1

Theoretical Analysis

MedKoo Cat#: 532805

Name: T-226296

CAS#: 331758-35-1

Chemical Formula: C26H27FN2O

Exact Mass: 402.2107

Molecular Weight: 402.51

Elemental Analysis: C, 77.58; H, 6.76; F, 4.72; N, 6.96; O, 3.97

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

T-226296, T 226296, T226296

IUPAC/Chemical Name

N-[6-(dimethylaminomethyl)-5,6,7,8-tetrahydronaphthalen-2-yl]-4-(4-fluorophenyl)benzamide

InChi Key

GXAQELJVODWLDD-UHFFFAOYSA-N

InChi Code

InChI=1S/C26H27FN2O/c1-29(2)17-18-3-4-23-16-25(14-11-22(23)15-18)28-26(30)21-7-5-19(6-8-21)20-9-12-24(27)13-10-20/h5-14,16,18H,3-4,15,17H2,1-2H3,(H,28,30)

SMILES Code

O=C(NC1=CC=C2CC(CN(C)C)CCC2=C1)C3=CC=C(C4=CC=C(F)C=C4)C=C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 402.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Högberg T, Frimurer TM, Sasmal PK. Melanin concentrating hormone receptor 1 (MCHR1) antagonists-Still a viable approach for obesity treatment? Bioorg Med Chem Lett. 2012 Oct 1;22(19):6039-47. doi: 10.1016/j.bmcl.2012.08.025. Epub 2012 Aug 19. PubMed PMID: 22954736. 2: Saito Y, Maruyama K. Identification of melanin-concentrating hormone receptor and its impact on drug discovery. J Exp Zool A Comp Exp Biol. 2006 Sep 1;305(9):761-8. Review. PubMed PMID: 16902961. 3: Basso AM, Bratcher NA, Gallagher KB, Cowart MD, Zhao C, Sun M, Esbenshade TA, Brune ME, Fox GB, Schmidt M, Collins CA, Souers AJ, Iyengar R, Vasudevan A, Kym PR, Hancock AA, Rueter LE. Lack of efficacy of melanin-concentrating hormone-1 receptor antagonists in models of depression and anxiety. Eur J Pharmacol. 2006 Jul 1;540(1-3):115-20. Epub 2006 May 6. PubMed PMID: 16765941. 4: Kowalski TJ, Farley C, Cohen-Williams ME, Varty G, Spar BD. Melanin-concentrating hormone-1 receptor antagonism decreases feeding by reducing meal size. Eur J Pharmacol. 2004 Aug 16;497(1):41-7. PubMed PMID: 15321733. 5: Vitale RM, Pedone C, De Benedetti PG, Fanelli F. Structural features of the inactive and active states of the melanin-concentrating hormone receptors: insights from molecular simulations. Proteins. 2004 Aug 15;56(3):430-48. PubMed PMID: 15229878. 6: Gao X, Hsu CK, Heinz LJ, Morin J, Shi Y, Shukla NK, Smiley DL, Xu J, Zhong B, Slieker LJ. Europium-labeled melanin-concentrating hormone analogues: ligands for measuring binding to melanin-concentrating hormone receptors 1 and 2. Anal Biochem. 2004 May 15;328(2):187-95. PubMed PMID: 15113696. 7: Takekawa S, Asami A, Ishihara Y, Terauchi J, Kato K, Shimomura Y, Mori M, Murakoshi H, Kato K, Suzuki N, Nishimura O, Fujino M. T-226296: a novel, orally active and selective melanin-concentrating hormone receptor antagonist. Eur J Pharmacol. 2002 Mar 8;438(3):129-35. PubMed PMID: 11909603.