MedKoo Cat#: 128871 | Name: Lipid 20b
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lipid 20b is a thiophene ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.

Chemical Structure

Lipid 20b
Lipid 20b
CAS#2921586-65-2

Theoretical Analysis

MedKoo Cat#: 128871

Name: Lipid 20b

CAS#: 2921586-65-2

Chemical Formula: C44H72N2O3S

Exact Mass: 708.5264

Molecular Weight: 709.13

Elemental Analysis: C, 74.53; H, 10.23; N, 3.95; O, 6.77; S, 4.52

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 Weeks
10mg USD 650.00 2 Weeks
25mg USD 1,150.00 2 Weeks
50mg USD 1,950.00 2 Weeks
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Related CAS #
No Data
Synonym
Lipid 20b; Lipid-20b; Lipid20b
IUPAC/Chemical Name
(9Z,12Z)-octadeca-9,12-dien-1-yl 2-((9Z,12Z)-octadeca-9,12-dienamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate
InChi Key
IGCXVXZVYNWGQF-MAZCIEHSSA-N
InChi Code
InChI=1S/C44H72N2O3S/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-37-49-44(48)42-39-35-36-45-38-40(39)50-43(42)46-41(47)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h11-14,17-20,45H,3-10,15-16,21-38H2,1-2H3,(H,46,47)/b13-11-,14-12-,19-17-,20-18-
SMILES Code
CCCCC/C=C\C/C=C\CCCCCCCCOC(C1=C(SC2=C1CCNC2)NC(CCCCCCC/C=C\C/C=C\CCCCC)=O)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 709.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Eygeris, Y., Gupta, M., Kim, J., et al. Thiophene-based lipids for mRNA delivery to pulmonary and retinal tissues. Proc. Natl. Acad. Sci. USA 121(11), e2307813120 (2024).