MedKoo Cat#: 565507 | Name: FeIII-PPIX ligand-18

Description:

WARNING: This product is for research use only, not for human or veterinary use.

FeIII-PPIX ligand-18 is a novel potent antimalarial agent, binding to ferriprotoporphyrin-ix (feiii-ppix) (kd = 33 nm) against chloroquine-resistant and sensitive strains of plasmodium falciparum

Chemical Structure

FeIII-PPIX ligand-18
FeIII-PPIX ligand-18
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 565507

Name: FeIII-PPIX ligand-18

CAS#: N/A

Chemical Formula: C16H19N3O

Exact Mass: 269.1528

Molecular Weight: 269.35

Elemental Analysis: C, 71.35; H, 7.11; N, 15.60; O, 5.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
FeIII-PPIX ligand-18; FeIII PPIX ligand 18; FeIIIPPIXligand18
IUPAC/Chemical Name
(E)-2-Isopropyl-5-methyl-4-((2-(pyridin-4-yl)hydrazono)methyl)phenol
InChi Key
XNFPWNDAFWNDDT-VCHYOVAHSA-N
InChi Code
InChI=1S/C16H19N3O/c1-11(2)15-9-13(12(3)8-16(15)20)10-18-19-14-4-6-17-7-5-14/h4-11,20H,1-3H3,(H,17,19)/b18-10+
SMILES Code
OC1=CC(C)=C(/C=N/NC2=CC=NC=C2)C=C1C(C)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 269.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tang J, Cai S, Ye C, Dong L. Biomarkers in IgG4-related disease: A systematic review. Semin Arthritis Rheum. 2019 Jun 28. pii: S0049-0172(19)30329-4. doi: 10.1016/j.semarthrit.2019.06.018. [Epub ahead of print] Review. PubMed PMID: 31280934. 2: Little AC, Pathanjeli P, Wu Z, Bao L, Goo LE, Yates JA, Oliver CR, Soellner MB, Merajver SD. IL-4/IL-13 Stimulated Macrophages Enhance Breast Cancer Invasion Via Rho-GTPase Regulation of Synergistic VEGF/CCL-18 Signaling. Front Oncol. 2019 May 31;9:456. doi: 10.3389/fonc.2019.00456. eCollection 2019. PubMed PMID: 31214501; PubMed Central PMCID: PMC6554436. 3: Tsuboi H, Iizuka-Koga M, Asashima H, Takahashi H, Kudo H, Ono Y, Honda F, Iizuka A, Segawa S, Abe S, Yagishita M, Yokosawa M, Kondo Y, Moriyama M, Matsumoto I, Nakamura S, Sumida T. Up-regulation and pathogenic roles of CCL18-CCR8 axis in IgG4-related disease. Mod Rheumatol. 2019 Jun 15:1-25. doi: 10.1080/14397595.2019.1632061. [Epub ahead of print] PubMed PMID: 31203743. 4: Pham TH, Bak Y, Kwon T, Kwon SB, Oh JW, Park JH, Choi YK, Hong JT, Yoon DY. Interleukin-32θ inhibits tumor-promoting effects of macrophage-secreted CCL18 in breast cancer. Cell Commun Signal. 2019 May 24;17(1):53. doi: 10.1186/s12964-019-0374-y. PubMed PMID: 31126309; PubMed Central PMCID: PMC6534939. 5: Huang H, Li J, Hu WJ, Chen C, Luo HQ, Tang XD, Zhou KY, Zhong WT, Li XY. The serum level of CC chemokine ligand 18 correlates with the prognosis of non-small cell lung cancer. Int J Biol Markers. 2019 Jun;34(2):156-162. doi: 10.1177/1724600819829758. Epub 2019 May 3. PubMed PMID: 31046524. 6: Malhotra P, Haslett P, Sherry B, Shepp DH, Barber P, Abshier J, Roy U, Schmidtmayerova H. Increased Plasma Levels of the TH2 chemokine CCL18 associated with low CD4+ T cell counts in HIV-1-infected Patients with a Suppressed Viral Load. Sci Rep. 2019 Apr 12;9(1):5963. doi: 10.1038/s41598-019-41588-1. PubMed PMID: 30979916; PubMed Central PMCID: PMC6461658. 7: Ma L, Wang H, Li Z, Geng X, Li M. Chemokine (C-C motif) ligand 18 is highly expressed in glioma tissues and promotes invasion of glioblastoma cells. J Cancer Res Ther. 2019;15(2):358-364. doi: 10.4103/jcrt.JCRT_360_17. PubMed PMID: 30964111. 8: Kopecky C, Pandzic E, Parmar A, Szajer J, Lee V, Dupuy A, Arthur A, Fok S, Whan R, Ryder WJ, Rye KA, Cochran BJ. Translocator protein localises to CD11b(+) macrophages in atherosclerosis. Atherosclerosis. 2019 May;284:153-159. doi: 10.1016/j.atherosclerosis.2019.03.011. Epub 2019 Mar 18. PubMed PMID: 30913515. 9: Liu M, Guo P, An J, Guo C, Lu F, Lei Y. Genome wide profiling of lncRNA and mRNA expression in CRSwNP. Mol Med Rep. 2019 May;19(5):3855-3863. doi: 10.3892/mmr.2019.10005. Epub 2019 Mar 5. PubMed PMID: 30864741. 10: Jing X, Peng J, Dou Y, Sun J, Ma C, Wang Q, Zhang L, Luo X, Kong B, Zhang Y, Wang L, Qu X. Macrophage ERα promoted invasion of endometrial cancer cell by mTOR/KIF5B-mediated epithelial to mesenchymal transition. Immunol Cell Biol. 2019 Jul;97(6):563-576. doi: 10.1111/imcb.12245. Epub 2019 Mar 14. PubMed PMID: 30779215. 11: Qin Y, Wang J, Zhu G, Li G, Tan H, Chen C, Pi L, She L, Chen X, Wei M, Li Z, Liu Z, Huang D, Liu Y, Zhang X. CCL18 promotes the metastasis of squamous cell carcinoma of the head and neck through MTDH-NF-κB signalling pathway. J Cell Mol Med. 2019 Apr;23(4):2689-2701. doi: 10.1111/jcmm.14168. Epub 2019 Feb 15. PubMed PMID: 30768878; PubMed Central PMCID: PMC6433669. 12: Shen XN, Miao D, Li JQ, Tan CC, Cao XP, Tan L, Yu JT. MAPT rs242557 variant is associated with hippocampus tau uptake on (18)F-AV-1451 PET in non-demented elders. Aging (Albany NY). 2019 Jan 31;11(3):874-884. doi: 10.18632/aging.101783. PubMed PMID: 30708351; PubMed Central PMCID: PMC6382414. 13: Tsai RM, Bejanin A, Lesman-Segev O, LaJoie R, Visani A, Bourakova V, O'Neil JP, Janabi M, Baker S, Lee SE, Perry DC, Bajorek L, Karydas A, Spina S, Grinberg LT, Seeley WW, Ramos EM, Coppola G, Gorno-Tempini ML, Miller BL, Rosen HJ, Jagust W, Boxer AL, Rabinovici GD. (18)F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes. Alzheimers Res Ther. 2019 Jan 31;11(1):13. doi: 10.1186/s13195-019-0470-7. PubMed PMID: 30704514; PubMed Central PMCID: PMC6357510. 14: Kapanadze T, Bankstahl JP, Wittneben A, Koestner W, Ballmaier M, Gamrekelashvili J, Krishnasamy K, Limbourg A, Ross TL, Meyer GJ, Haller H, Bengel FM, Limbourg FP. Multimodal and Multiscale Analysis Reveals Distinct Vascular, Metabolic and Inflammatory Components of the Tissue Response to Limb Ischemia. Theranostics. 2019 Jan 1;9(1):152-166. doi: 10.7150/thno.27175. eCollection 2019. PubMed PMID: 30662559; PubMed Central PMCID: PMC6332799. 15: Liang S, Zheng J, Wu W, Li Q, Saw PE, Chen J, Xu X, Yao H, Yao Y. A Robust Nanoparticle Platform for RNA Interference in Macrophages to Suppress Tumor Cell Migration. Front Pharmacol. 2018 Dec 14;9:1465. doi: 10.3389/fphar.2018.01465. eCollection 2018. PubMed PMID: 30618757; PubMed Central PMCID: PMC6302002. 16: Selvaggi P, Hawkins PCT, Dipasquale O, Rizzo G, Bertolino A, Dukart J, Sambataro F, Pergola G, Williams SCR, Turkheimer F, Zelaya F, Veronese M, Mehta MA. Increased cerebral blood flow after single dose of antipsychotics in healthy volunteers depends on dopamine D2 receptor density profiles. Neuroimage. 2019 Mar;188:774-784. doi: 10.1016/j.neuroimage.2018.12.028. Epub 2018 Dec 13. PubMed PMID: 30553916. 17: Raghu G, Richeldi L, Jagerschmidt A, Martin V, Subramaniam A, Ozoux ML, Esperet CA, Soubrane C. Idiopathic Pulmonary Fibrosis: Prospective, Case-Controlled Study of Natural History and Circulating Biomarkers. Chest. 2018 Dec;154(6):1359-1370. doi: 10.1016/j.chest.2018.08.1083. PubMed PMID: 30526970. 18: Su Y, Zhou Y, Sun YJ, Wang YL, Yin JY, Huang YJ, Zhang JJ, He AN, Han K, Zhang HZ, Yao Y, Lv XB, Hu HY. Macrophage-derived CCL18 promotes osteosarcoma proliferation and migration by upregulating the expression of UCA1. J Mol Med (Berl). 2019 Jan;97(1):49-61. doi: 10.1007/s00109-018-1711-0. Epub 2018 Nov 13. PubMed PMID: 30426155. 19: Huang H, Li J, Hu WJ, Chen MH, Chen SS, Chen C, Luo HQ, Zhou KY, Liu XG, Li XY. Positive expression of chemokine (C-C Motif) ligand 18 and prognosis in cancer: A meta-analysis. J BUON. 2018 Jul-Aug;23(4):1185-1194. PubMed PMID: 30358230. 20: Bevan-Jones RW, Cope TE, Jones SP, Passamonti L, Hong YT, Fryer T, Arnold R, Coles JP, Aigbirhio FA, Patterson K, O'Brien JT, Rowe JB. [(18)F]AV-1451 binding is increased in frontotemporal dementia due to C9orf72 expansion. Ann Clin Transl Neurol. 2018 Sep 14;5(10):1292-1296. doi: 10.1002/acn3.631. eCollection 2018 Oct. PubMed PMID: 30349864; PubMed Central PMCID: PMC6186940.