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MedKoo Cat#: 128856 | Name: ASP0965

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ASP0965 is a potent, orally active and brain-penetrable NLRP3 inflammasome inhibitor (IC50 = 8.4 nM).

Chemical Structure

ASP0965
ASP0965
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128856

Name: ASP0965

CAS#: N/A

Chemical Formula: C19H22F3N3O2

Exact Mass: 381.1664

Molecular Weight: 381.40

Elemental Analysis: C, 59.83; H, 5.81; F, 14.94; N, 11.02; O, 8.39

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
ASP0965; ASP-0965; ASP 0965
IUPAC/Chemical Name
2-(6-(((1R,2R)-2-hydroxycyclohexyl)amino)-4,5-dimethylpyridazin-3-yl)-5-(trifluoromethyl)phenol
InChi Key
ZZWSXJAUWNSSBZ-HUUCEWRRSA-N
InChi Code
InChI=1S/C19H22F3N3O2/c1-10-11(2)18(23-14-5-3-4-6-15(14)26)25-24-17(10)13-8-7-12(9-16(13)27)19(20,21)22/h7-9,14-15,26-27H,3-6H2,1-2H3,(H,23,25)/t14-,15-/m1/s1
SMILES Code
CC1=C(C)C(C2=CC=C(C(F)(F)F)C=C2O)=NN=C1N[C@H]3[C@H](O)CCCC3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 381.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Inagaki Y, Kamikubo T, Kuriwaki I, Watanabe J, Yamaki S, Iida M, Tomita K, Kakefuda K, Kurokawa J, Kiso T, Saba K, Koike T. Discovery of 2-(6-{[(1R,2R)-2-hydroxycyclohexyl]amino}-4,5-dimethylpyridazin-3-yl)-5-(trifluoromethyl)phenol (ASP0965): A potent, orally active and brain-penetrable NLRP3 inflammasome inhibitor with a novel scaffold for the treatment of α-synucleinopathy. Bioorg Med Chem. 2025 Feb 1;118:118042. doi: 10.1016/j.bmc.2024.118042. Epub 2024 Dec 12. PMID: 39742857.