MedKoo Cat#: 146299 | Name: Pratol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pratol is a naturally occurring O-methylated flavone found in plants such as red clover (Trifolium pratense). It exhibits various biological activities, including anti-inflammatory, antioxidant, and phytoestrogenic effects. Pratol functions by modulating signaling pathways such as NF-κB and MAPK, and may also bind to estrogen receptors, influencing gene expression and cellular responses. Due to these properties, it is being explored for use in nutraceuticals and as a lead compound in drug discovery for hormone-related and inflammatory conditions.

Chemical Structure

Pratol
Pratol
CAS#487-24-1

Theoretical Analysis

MedKoo Cat#: 146299

Name: Pratol

CAS#: 487-24-1

Chemical Formula: C16H12O4

Exact Mass: 268.0736

Molecular Weight: 268.27

Elemental Analysis: C, 71.64; H, 4.51; O, 23.86

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Pratol;
IUPAC/Chemical Name
7-hydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one
InChi Key
SQVXWIUVAILQRH-UHFFFAOYSA-N
InChi Code
1S/C16H12O4/c1-19-12-5-2-10(3-6-12)15-9-14(18)13-7-4-11(17)8-16(13)20-15/h2-9,17H,1H3
SMILES Code
COC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(O)C=C3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 268.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chung YC, Kim S, Kim JH, Lee GS, Lee JN, Lee NH, Hyun CG. Pratol, an O-Methylated Flavone, Induces Melanogenesis in B16F10 Melanoma Cells via p-p38 and p-JNK Upregulation. Molecules. 2017 Oct 11;22(10):1704. doi: 10.3390/molecules22101704. PMID: 29019920; PMCID: PMC6151583. 2: Huo Y, Guo C, Zhang QY, Chen WS, Zheng HC, Rahman K, Qin LP. Antinociceptive activity and chemical composition of constituents from Caragana microphylla seeds. Phytomedicine. 2007 Feb;14(2-3):143-6. doi: 10.1016/j.phymed.2006.03.008. Epub 2006 May 16. PMID: 16707255.