VV261 | A nucleoside prodrug

MedKoo Cat#: 128843 | Name: VV261

Description:

WARNING: This product is for research use only, not for human or veterinary use.

VV261 is a nucleoside prodrug. VV261 is active against Severe fever with thrombocytopenia syndrome virus (SFTSV).

Chemical Structure

VV261

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128843

Name: VV261

CAS#: N/A

Chemical Formula: C28H34FN3O11

Exact Mass: 607.2177

Molecular Weight: 607.59

Elemental Analysis: C, 55.35; H, 5.64; F, 3.13; N, 6.92; O, 28.97

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

VV261; VV-261; VV 261

IUPAC/Chemical Name

(2S,3S,4R,5R)-2-fluoro-2-((isobutyryloxy)methyl)-5-(3-((nicotinoyloxy)methyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl bis(2-methylpropanoate)

InChi Key

NQRKQWPVFDFSBT-BUUPBASBSA-N

InChi Code

InChI=1S/C28H34FN3O11/c1-15(2)23(34)39-13-28(29)21(42-25(36)17(5)6)20(41-24(35)16(3)4)22(43-28)31-11-9-19(33)32(27(31)38)14-40-26(37)18-8-7-10-30-12-18/h7-12,15-17,20-22H,13-14H2,1-6H3/t20-,21+,22-,28-/m1/s1

SMILES Code

CC(C)C(OC[C@]1(F)[C@@H](OC(C(C)C)=O)[C@@H](OC(C(C)C)=O)[C@H](N2C(N(COC(C3=CC=CN=C3)=O)C(C=C2)=O)=O)O1)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 607.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Cheng Y, Zheng W, Dong X, Sun T, Xu M, Xiang L, Li J, Wang H, Jian X, Yu J, Li P, Hu T, Tian G, Jiang X, Zhang L, Aisa HA, Xie Y, Xiao G, Shen J. Design and Development of a Novel Oral 4'-Fluorouridine Double Prodrug VV261 against SFTSV. J Med Chem. 2025 Apr 28. doi: 10.1021/acs.jmedchem.5c00626. Epub ahead of print. PMID: 40294286.