MedKoo Cat#: 128274 | Name: S-15176

Description:

WARNING: This product is for research use only, not for human or veterinary use.

S-15176 is a CPT inhibitor.

Chemical Structure

S-15176
S-15176
CAS#148089-70-7

Theoretical Analysis

MedKoo Cat#: 128274

Name: S-15176

CAS#: 148089-70-7

Chemical Formula: C31H48N2O4S

Exact Mass: 544.3335

Molecular Weight: 544.80

Elemental Analysis: C, 68.35; H, 8.88; N, 5.14; O, 11.75; S, 5.88

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
S-15176; S 15176; S15176
IUPAC/Chemical Name
2,6-ditert-butyl-4-[3-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]propylsulfanyl]phenol
InChi Key
GMNFEHDZQAODON-UHFFFAOYSA-N
InChi Code
InChI=1S/C31H48N2O4S/c1-30(2,3)24-19-23(20-25(27(24)34)31(4,5)6)38-18-10-13-32-14-16-33(17-15-32)21-22-11-12-26(35-7)29(37-9)28(22)36-8/h11-12,19-20,34H,10,13-18,21H2,1-9H3
SMILES Code
OC1=C(C(C)(C)C)C=C(SCCCN2CCN(CC3=CC=C(OC)C(OC)=C3OC)CC2)C=C1C(C)(C)C
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 544.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Albengres E, Le Louët H, d'Athis P, Tillement JP. S15176 and S16950 interaction with Cyclosporin A antiproliferative effect on cultured human lymphocytes. Fundam Clin Pharmacol. 2001 Feb;15(1):41-6. doi: 10.1046/j.1472-8206.2001.00001.x. PMID: 11468012. 2: Belosludtseva NV, Starinets VS, Semenova AA, Igoshkina AD, Dubinin MV, Belosludtsev KN. S-15176 Difumarate Salt Can Impair Mitochondrial Function through Inhibition of the Respiratory Complex III and Permeabilization of the Inner Mitochondrial Membrane. Biology (Basel). 2022 Feb 27;11(3):380. doi: 10.3390/biology11030380. PMID: 35336754; PMCID: PMC8945000. 3: Hamdan M, Urien S, Le Louet H, Tillement JP, Morin D. Inhibition of mitochondrial carnitine palmitoyltransferase-1 by a trimetazidine derivative, S-15176. Pharmacol Res. 2001 Aug;44(2):99-104. doi: 10.1006/phrs.2001.0829. PMID: 11516258. 4: Elimadi A, Jullien V, Tillement JP, Morin D. S-15176 inhibits mitochondrial permeability transition via a mechanism independent of its antioxidant properties. Eur J Pharmacol. 2003 May 9;468(2):93-101. doi: 10.1016/s0014-2999(03)01671-6. PMID: 12742516. 5: Elimadi A, Sapena R, Settaf A, Le Louet H, Tillement J, Morin D. Attenuation of liver normothermic ischemia--reperfusion injury by preservation of mitochondrial functions with S-15176, a potent trimetazidine derivative. Biochem Pharmacol. 2001 Aug 15;62(4):509-16. doi: 10.1016/s0006-2952(01)00676-1. PMID: 11448461. 6: Kawashima S, Yamamoto T, Horiuchi Y, Fujiwara K, Gouda S, Yoshimura Y, Yamamoto A, Inotani Y, Yamashita K, Kitamura S, Terada H, Kanematsu M, Shishido K, Shinohara Y. S-15176 and its methylated derivative suppress the CsA- insensitive mitochondrial permeability transition and subsequent cytochrome c release induced by silver ion, and show weak protonophoric activity. Mol Cell Biochem. 2011 Dec;358(1-2):45-51. doi: 10.1007/s11010-011-0919-x. Epub 2011 Jun 18. PMID: 21688046. 7: Erdoğan H, Tunçdemir M, Kelten B, Akdemir O, Karaoğlan A, Taşdemiroğlu E. The Effects of Difumarate Salt S-15176 after Spinal Cord Injury in Rats. J Korean Neurosurg Soc. 2015 Jun;57(6):445-54. doi: 10.3340/jkns.2015.57.6.445. Epub 2015 Jun 30. PMID: 26180614; PMCID: PMC4502243. 8: Belosludtseva NV, Starinets VS, Pavlik LL, Mikheeva IB, Dubinin MV, Belosludtsev KN. The Effect of S-15176 Difumarate Salt on Ultrastructure and Functions of Liver Mitochondria of C57BL/6 Mice with Streptozotocin/High-Fat Diet-Induced Type 2 Diabetes. Biology (Basel). 2020 Sep 24;9(10):309. doi: 10.3390/biology9100309. PMID: 32987717; PMCID: PMC7598715. 9: Settaf A, Zahidy M, Elimadi A, Sapena R, Alsamad IA, Tillement J, Morin D. S-15176 reduces the hepatic injury in rats subjected to experimental ischemia and reperfusion. Eur J Pharmacol. 2000 Oct 13;406(2):281-92. doi: 10.1016/s0014-2999(00)00599-9. PMID: 11020492. 10: Morin D, Zini R, Berdeaux A, Tillement JP. Effect of the mitochondrial transition pore inhibitor, S-15176, on rat liver mitochondria: ATP synthase modulation and mitochondrial uncoupling induction. Biochem Pharmacol. 2006 Sep 28;72(7):911-8. doi: 10.1016/j.bcp.2006.06.035. Epub 2006 Aug 1. PMID: 16879802.