Inauhzin is a potent SIRT inhibitor, which effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress. Moreover, Inauhzin stabilizes p53 by increasing p53 acetylation and preventing MDM2-mediated ubiquitylation of p53 in cells, though not directly in vitro. Remarkably, Inauhzin inhibits cell proliferation, induces senescence and tumour-specific apoptosis, and represses the growth of xenograft tumours derived from p53-harbouring H460 and HCT116 cells without causing apparent toxicity to normal tissues and the tumour-bearing SCID mice.
MedKoo Cat#: 406518
Name: Inauhzin
CAS#: 309271-94-1
Chemical Formula: C25H19N5OS2
Exact Mass: 469.1031
Molecular Weight: 469.58
Elemental Analysis: C, 63.94; H, 4.08; N, 14.91; O, 3.41; S, 13.66
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 20.0 | 42.59 | |
| DMF:PBS (pH 7.2) (1:1) | 0.3 | 0.64 | |
| DMSO | 43.0 | 91.57 |
The following data is based on the product molecular weight 469.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
