BEN-28010 is a freely brainpenetrant, potent, and selective CHK1 inhibitor (IC50 = 4 nM), In vivo pharmacological studies demonstrated efficacy of orally administered BEN-28010 in several GBM CDX and PDX models as a monotherapy and in combination with ionizing radiation, including improved overall survival in an intracranially implanted GBM PDX mouse model.
MedKoo Cat#: 128819
Name: BEN-28010
CAS#: N/A
Chemical Formula: C20H22N8
Exact Mass: 374.1967
Molecular Weight: 374.45
Elemental Analysis: C, 64.15; H, 5.92; N, 29.93
The following data is based on the product molecular weight 374.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
