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MedKoo Cat#: 128802 | Name: HM70186

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HM70186 is a medoxomil ester of EXP3174 which is an active metabolite of angiotensin Ⅱ receptor blocker losartan. HM70186 could be a promising candidate for the treatment of hypertension accompanied by hepatic dysfunction.

Chemical Structure

HM70186
HM70186
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128802

Name: HM70186

CAS#: N/A

Chemical Formula: C27H25ClN6O5

Exact Mass: 548.1575

Molecular Weight: 548.98

Elemental Analysis: C, 59.07; H, 4.59; Cl, 6.46; N, 15.31; O, 14.57

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
HM70186; HM-70186; HM 70186
IUPAC/Chemical Name
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-chloro-1H-imidazole-5-carboxylate
InChi Key
YCGQJPTXLREKSZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H25ClN6O5/c1-3-4-9-22-29-24(28)23(26(35)37-15-21-16(2)38-27(36)39-21)34(22)14-17-10-12-18(13-11-17)19-7-5-6-8-20(19)25-30-32-33-31-25/h5-8,10-13H,3-4,9,14-15H2,1-2H3,(H,30,31,32,33)
SMILES Code
O=C1OC(COC(C2=C(Cl)N=C(CCCC)N2CC3=CC=C(C4=C(C5=NN=NN5)C=CC=C4)C=C3)=O)=C(C)O1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 548.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Choi JH, Shin S, Park D, Jeon JH, Choi BH, Jang MJ, Joo SS, Oh KW, Hong JT, Suh KH, Kim YB. Comparative antihypertensive activities of losartan and HM70186 in rats with hepatic dysfunction. Arch Pharm Res. 2009 Jul;32(7):1005-11. doi: 10.1007/s12272-009-1705-0. Epub 2009 Jul 31. PMID: 19641881. 2: Lee S. Comparative evaluation of the antihypertensive activities of losartan and HM70186 during liver dysfunction. Arch Pharm Res. 2009 Jul;32(7):965-6. doi: 10.1007/s12272-009-1620-4. PMID: 19641875.