TK145 | SHP2 inhibitor

MedKoo Cat#: 128780 | Name: TK-145

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TK145 is an allosteric SHP2 inhibitor.

Chemical Structure

TK-145

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128780

Name: TK-145

CAS#: N/A

Chemical Formula: C16H19Cl2N5

Exact Mass: 351.1018

Molecular Weight: 352.26

Elemental Analysis: C, 54.55; H, 5.44; Cl, 20.13; N, 19.88

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

TK-145; TK 145; TK145

IUPAC/Chemical Name

2-(4-amino-4-methylpiperidin-1-yl)-5-(2,3-dichlorophenyl)pyrimidin-4-amine

InChi Key

BBHWSBPGMHSPCC-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H19Cl2N5/c1-16(20)5-7-23(8-6-16)15-21-9-11(14(19)22-15)10-3-2-4-12(17)13(10)18/h2-4,9H,5-8,20H2,1H3,(H2,19,21,22)

SMILES Code

ClC1=C(C2=CN=C(N3CCC(C)(N)CC3)N=C2N)C=CC=C1Cl

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 352.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Tojjari A, Saeed A, Sadeghipour A, Kurzrock R, Cavalcante L. Overcoming Immune Checkpoint Therapy Resistance with SHP2 Inhibition in Cancer and Immune Cells: A Review of the Literature and Novel Combinatorial Approaches. Cancers (Basel). 2023 Nov 13;15(22):5384. doi: 10.3390/cancers15225384. PMID: 38001644; PMCID: PMC10670368.