ER-464195-01 is a Calreticulin (CRT) inhibitor. ER-464195-01 demonstrated significant therapeutic efficacy in mouse models of colitis. Specifically, oral administration of the compound at 10 mg/kg/day markedly reduced disease severity, as evidenced by improvements in body weight, colon length, and histological scores. Mechanistically, ER-464195-01 was shown to disrupt the interaction between calreticulin and integrin α subunits, leading to the suppression of pro-inflammatory cytokine production and the promotion of anti-inflammatory macrophage polarization. These findings suggest that ER-464195-01 holds promise as a novel therapeutic agent for the treatment of IBD by modulating immune cell function and inflammatory responses .
MedKoo Cat#: 556392
Name: ER-464195-01 HCl
CAS#: 859218-37-4 (HCl)
Chemical Formula: C23H39ClN2
Exact Mass: 0.0000
Molecular Weight: 379.03
Elemental Analysis: C, 72.88; H, 10.37; Cl, 9.35; N, 7.39
The following data is based on the product molecular weight 379.03 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
