GSK2334470 is a potent 3-phosphoinositide-dependent protein kinase (PDK1) inhibitor (IC50 ~ 10 nM), which does not suppress the activity of 93 other protein kinases including 13 AGC-kinases most related to PDK1 at 500-fold higher concentrations. GSK2334470 also inhibited T-loop phosphorylation and activation of Akt. GSK2334470 will be a useful tool for delineating the roles of PDK1 in biological processes.
MedKoo Cat#: 406156
Name: GSK2334470
CAS#: 1227911-45-6
Chemical Formula: C25H34N8O
Exact Mass: 462.2856
Molecular Weight: 462.60
Elemental Analysis: C, 64.91; H, 7.41; N, 24.22; O, 3.46
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 20.0 | 43.23 | |
| DMSO | 52.1 | 112.55 | |
| Ethanol | 52.8 | 114.04 | |
| Ethanol:PBS (pH 7.2) (1:1) | 0.5 | 1.08 |
The following data is based on the product molecular weight 462.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
