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MedKoo Cat#: 125000 | Name: LAS194046

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LAS194046 is a JAK inhibitor designed for inhaled administration.

Chemical Structure

LAS194046
LAS194046
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 125000

Name: LAS194046

CAS#: N/A

Chemical Formula: C34H41FN10O2

Exact Mass: 640.3400

Molecular Weight: 640.77

Elemental Analysis: C, 63.73; H, 6.45; F, 2.96; N, 21.86; O, 4.99

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
LAS194046; LAS 194046; LAS-194046
IUPAC/Chemical Name
(R)-3-(3-((6-(4-(4-(2-(dimethylamino)ethoxy)benzyl)piperazin-1-yl)-5-fluoro-2-(pyrazolo[1,5-a]pyridin-3-yl)pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile
InChi Key
IOSNQXYLFHEZTC-AREMUKBSSA-N
InChi Code
InChI=1S/C34H41FN10O2/c1-41(2)20-21-47-27-10-8-25(9-11-27)23-42-16-18-43(19-17-42)34-31(35)33(38-26-6-5-14-44(24-26)30(46)12-13-36)39-32(40-34)28-22-37-45-15-4-3-7-29(28)45/h3-4,7-11,15,22,26H,5-6,12,14,16-21,23-24H2,1-2H3,(H,38,39,40)/t26-/m1/s1
SMILES Code
FC(C(N[C@@H]1CCCN(C(CC#N)=O)C1)=N2)=C(N3CCN(CC4=CC=C(OCCN(C)C)C=C4)CC3)N=C2C5=C6N(N=C5)C=CC=C6
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 640.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Milara J, Ballester B, de Diego A, Calbet M, Ramis I, Miralpeix M, Cortijo J. The pan-JAK inhibitor LAS194046 reduces neutrophil activation from severe asthma and COPD patients in vitro. Sci Rep. 2022 Mar 24;12(1):5132. doi: 10.1038/s41598-022-09241-6. PMID: 35332239; PMCID: PMC8948298. 2: Calbet M, Ramis I, Calama E, Carreño C, Paris S, Maldonado M, Orellana A, Calaf E, Pauta M, De Alba J, Bach J, Miralpeix M. Novel Inhaled Pan-JAK Inhibitor, LAS194046, Reduces Allergen-Induced Airway Inflammation, Late Asthmatic Response, and pSTAT Activation in Brown Norway Rats. J Pharmacol Exp Ther. 2019 Aug;370(2):137-147. doi: 10.1124/jpet.119.256263. Epub 2019 May 13. PMID: 31085698.