Umuhengerin | CAS#29215-55-2 | flavone

MedKoo Cat#: 146207 | Name: Umuhengerin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Umuhengerin is a naturally occurring flavone compound isolated from certain medicinal plants, such as Psiadia species. It belongs to the class of polymethoxylated flavonoids, known for their antioxidant, anti-inflammatory, and potential anticancer properties. Although its exact mechanism of action is not fully elucidated, umuhengerin is believed to modulate cellular signaling pathways, including those related to oxidative stress and inflammation, possibly through inhibition of enzymes like COX or modulation of NF-κB activity. Its applications lie primarily in natural product research and drug discovery, particularly for therapeutic agents targeting inflammation and oxidative damage.

Chemical Structure

Umuhengerin

CAS#29215-55-2

Theoretical Analysis

MedKoo Cat#: 146207

Name: Umuhengerin

CAS#: 29215-55-2

Chemical Formula: C20H20O8

Exact Mass: 388.1158

Molecular Weight: 388.37

Elemental Analysis: C, 61.85; H, 5.19; O, 32.96

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Umuhengerin;

IUPAC/Chemical Name

5-hydroxy-6,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one

InChi Key

QULPQWKDDOBIOC-UHFFFAOYSA-N

InChi Code

1S/C20H20O8/c1-23-14-6-10(7-15(24-2)19(14)26-4)12-8-11(21)17-13(28-12)9-16(25-3)20(27-5)18(17)22/h6-9,22H,1-5H3

SMILES Code

COC1=CC(=CC(OC)=C1OC)C2=CC(=O)C3=C(O)C(OC)=C(OC)C=C3O2

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 388.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Sirwi A, El Sayed NS, Abdallah HM, Ibrahim SRM, Mohamed GA, El-Halawany AM, Safo MK, Abdel Rasheed NO. Umuhengerin Neuroprotective Effects in Streptozotocin-Induced Alzheimer's Disease Mouse Model via Targeting Nrf2 and NF-Kβ Signaling Cascades. Antioxidants (Basel). 2021 Dec 18;10(12):2011. doi: 10.3390/antiox10122011. PMID: 34943114; PMCID: PMC8698785. 2: Rwangabo PC, Claeys M, Pieters L, Corthout J, Vanden Berghe DA, Vlietinck AJ. Umuhengerin, a new antimicrobially active flavonoid from Lantana trifolia. J Nat Prod. 1988 Sep-Oct;51(5):966-8. doi: 10.1021/np50059a026. PMID: 3204384. 3: Toklo PM, Yayi Ladekan E, Linden A, Hounzangbe-Adote S, Kouam SF, Gbenou JD. Anthelmintic flavonoids and other compounds from Combretum glutinosum Perr. ex DC (Combretaceae) leaves. Acta Crystallogr C Struct Chem. 2021 Sep 1;77(Pt 9):505-512. doi: 10.1107/S2053229621007841. Epub 2021 Aug 6. PMID: 34482293; PMCID: PMC8418671. 4: Abdallah HM, Hassan NA, El-Halawany AM, Mohamed GA, Safo MK, El-Bassossy HM. Major flavonoids from Psiadia punctulata produce vasodilation via activation of endothelial dependent NO signaling. J Adv Res. 2020 Jan 3;24:273-279. doi: 10.1016/j.jare.2020.01.002. PMID: 32382447; PMCID: PMC7200196. 5: Abdallah HM, Zakaria EM, El-Halawany AM, Mohamed GA, Safo MK, El-Bassossy HM. Psiadia punctulata major flavonoids alleviate exaggerated vasoconstriction produced by advanced glycation end products. PLoS One. 2019 Sep 6;14(9):e0222101. doi: 10.1371/journal.pone.0222101. PMID: 31491007; PMCID: PMC6730914. 6: Abdallah HM, El-Bassossy HM, El-Halawany AM, Ahmed TA, Mohamed GA, Malebari AM, Hassan NA. Self-Nanoemulsifying Drug Delivery System Loaded with Psiadia punctulata Major Metabolites for Hypertensive Emergencies: Effect on Hemodynamics and Cardiac Conductance. Front Pharmacol. 2021 Jun 10;12:681070. doi: 10.3389/fphar.2021.681070. PMID: 34177590; PMCID: PMC8222910. 7: Sawadogo WR, Cerella C, Al-Mourabit A, Moriou C, Teiten MH, Guissou IP, Dicato M, Diederich M. Cytotoxic, Antiproliferative and Pro-Apoptotic Effects of 5-Hydroxyl-6,7,3',4',5'-Pentamethoxyflavone Isolated from Lantana ukambensis. Nutrients. 2015 Dec 10;7(12):10388-97. doi: 10.3390/nu7125537. PMID: 26690473; PMCID: PMC4690089. 8: Dong P, Qiu P, Zhu Y, Li S, Ho CT, McClements DJ, Xiao H. Simultaneous determination of four 5-hydroxy polymethoxyflavones by reversed-phase high performance liquid chromatography with electrochemical detection. J Chromatogr A. 2010 Jan 29;1217(5):642-7. doi: 10.1016/j.chroma.2009.11.097. Epub 2009 Dec 4. PMID: 20022018. 9: Peng A, Qu X, Li H, Gao L, Yu B, Yang H. [Isolation and purification of flavones from Murraya exotica L. by high-speed counter-current chromatography]. Se Pu. 2010 Apr;28(4):383-7. Chinese. doi: 10.3724/sp.j.1123.2010.00383. PMID: 20712121.