Hexylparaben | CAS#1083-27-8 | biochemical

MedKoo Cat#: 146178 | Name: Hexylparaben

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hexylparaben is a chemical compound commonly used as a preservative in cosmetics, personal care products, and pharmaceuticals due to its antimicrobial properties. It works by inhibiting the growth of bacteria, fungi, and mold, helping to extend the shelf life of these products. Hexylparaben functions by disrupting the cellular processes of microorganisms, particularly by interfering with their cell membrane integrity. While it is effective in preventing microbial contamination, concerns have been raised about its potential endocrine-disrupting effects, as it may mimic estrogen in the body when absorbed.

Chemical Structure

Hexylparaben

CAS#1083-27-8

Theoretical Analysis

MedKoo Cat#: 146178

Name: Hexylparaben

CAS#: 1083-27-8

Chemical Formula: C13H18O3

Exact Mass: 222.1256

Molecular Weight: 222.28

Elemental Analysis: C, 70.24; H, 8.16; O, 21.59

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Hexylparaben;

IUPAC/Chemical Name

hexyl 4-hydroxybenzoate

InChi Key

ULULAZKOCFNOIM-UHFFFAOYSA-N

InChi Code

1S/C13H18O3/c1-2-3-4-5-10-16-13(15)11-6-8-12(14)9-7-11/h6-9,14H,2-5,10H2,1H3

SMILES Code

CCCCCCOC(=O)C1=CC=C(O)C=C1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 222.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Inderbinen SG, Kley M, Zogg M, Sellner M, Fischer A, Kędzierski J, Boudon S, Jetten AM, Smieško M, Odermatt A. Activation of retinoic acid-related orphan receptor γ(t) by parabens and benzophenone UV-filters. Toxicology. 2022 Apr 15;471:153159. doi: 10.1016/j.tox.2022.153159. Epub 2022 Mar 23. PMID: 35337918; PMCID: PMC11046913. 2: Chen Z, Gong C, Tang Y, Zhu Y, Wang S, Ge RS, Ying Y. Inhibitory effects of parabens on human and rat 17β-hydroxysteroid dehydrogenase 1: Mechanisms of action and impact on hormone synthesis. Toxicology. 2024 Aug;506:153873. doi: 10.1016/j.tox.2024.153873. Epub 2024 Jul 8. Erratum in: Toxicology. 2025 Jan;510:153991. doi: 10.1016/j.tox.2024.153991. PMID: 38986729. 3: Xiang J, Zhong M, Zhang Q, Zhu Y, Pan P, Li H, Fei Q, Ou R, Ge RS, Zhang W. Effects of parabens on human and rat placental 3β-hydroxysteroid dehydrogenase isoforms: Structure activity relationship and docking analysis. J Steroid Biochem Mol Biol. 2025 Jan;245:106638. doi: 10.1016/j.jsbmb.2024.106638. Epub 2024 Nov 19. PMID: 39566855. 4: Fujino C, Watanabe Y, Sanoh S, Hattori S, Nakajima H, Uramaru N, Kojima H, Yoshinari K, Ohta S, Kitamura S. Comparative study of the effect of 17 parabens on PXR-, CAR- and PPARα-mediated transcriptional activation. Food Chem Toxicol. 2019 Nov;133:110792. doi: 10.1016/j.fct.2019.110792. Epub 2019 Aug 28. PMID: 31472229. 5: Yano K, Masaoka Y, Kataoka M, Sakuma S, Yamashita S. Mechanisms of membrane transport of poorly soluble drugs: role of micelles in oral absorption processes. J Pharm Sci. 2010 Mar;99(3):1336-45. doi: 10.1002/jps.21919. PMID: 19743502.