Synonym
NRA-0562; NRA0562; NRA 0562
IUPAC/Chemical Name
2-Thiazolecarboxamide, 5-(2-(4-(6-fluoro-1H-indol-3-yl)-1-piperidinyl)ethyl)-4-(4-fluorophenyl)-
InChi Key
KGCLWPBGLDFQHP-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H24F2N4OS/c26-17-3-1-16(2-4-17)23-22(33-25(30-23)24(28)32)9-12-31-10-7-15(8-11-31)20-14-29-21-13-18(27)5-6-19(20)21/h1-6,13-15,29H,7-12H2,(H2,28,32)
SMILES Code
O=C(C1=NC(C2=CC=C(F)C=C2)=C(CCN3CCC(C4=CNC5=C4C=CC(F)=C5)CC3)S1)N
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
466.55
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Hirota S, Kawashima N, Chaki S, Okuyama S. Neuropharmacological profile of an atypical antipsychotic, NRA0562. CNS Drug Rev. 2003 Winter;9(4):375-88. doi: 10.1111/j.1527-3458.2003.tb00261.x. PMID: 14647530; PMCID: PMC6741651.
2: Funakoshi T, Chaki S, Kawashima N, Suzuki Y, Yoshikawa R, Kumagai T, Nakazato A, Kameo K, Goto M, Okuyama S. In vitro and in vivo pharmacological profile of 5 -[2-[4-(6-fluoro-1H-indole-3-yl)piperidin-1-yl]ethyl]-4-(4-fluorophenyl)thiazole -2-carboxylic acid amide (NRA0562), a novel and putative atypical antipsychotic. Life Sci. 2002 Aug 9;71(12):1371-84. doi: 10.1016/s0024-3205(02)01863-5. PMID: 12127158.
3: Takamori K, Funakoshi T, Hirota S, Chaki S, Kameo K. Antipsychotic profile of 5-[2-[4-(6-fluoro-1H-indole-3-yl)piperidin-1-yl]ethyl]-4-(4-fluorophenyl)thiazol e-2-carboxylic acid amide (NRA0562) in rats. Life Sci. 2002 Jul 12;71(8):947-52. doi: 10.1016/s0024-3205(02)01766-6. PMID: 12084391.
4: Kawashima N, Funakoshi T, Omura T, Chaki S, Kameo K, Okuyama S. Neuropharmacological profiles of a novel atypical antipsychotic, NRA0562, in rats. Eur J Pharmacol. 2001 Jun 29;423(1):27-33. doi: 10.1016/s0014-2999(01)01085-8. Erratum in: Eur J Pharmacol 2001 Oct 12;428(3):389-90. PMID: 11438303.
