GSK-554418A | CAS#871819-90-8 | CB(2) Agonist

MedKoo Cat#: 525228 | Name: GSK-554418A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSK-554418A is a novel azaindole CB(2) agonists. GSK-554418A is used for the treatment of chronic pain. This compound was efficacious in the acute model and the chronic joint pain model.

Chemical Structure

GSK-554418A

CAS#871819-90-8

Theoretical Analysis

MedKoo Cat#: 525228

Name: GSK-554418A

CAS#: 871819-90-8

Chemical Formula: C19H19ClN4O2

Exact Mass: 370.1197

Molecular Weight: 370.83

Elemental Analysis: C, 61.54; H, 5.16; Cl, 9.56; N, 15.11; O, 8.63

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

GSK-554418A; GSK 554418A; GSK554418A .

IUPAC/Chemical Name

Methanone, (4-((3-chlorophenyl)amino)-1-methyl-1H-pyrrolo(3,2-C)pyridin-7-yl)-4-morpholinyl-

InChi Key

VARGWBUXBMFVJN-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H19ClN4O2/c1-23-6-5-15-17(23)16(19(25)24-7-9-26-10-8-24)12-21-18(15)22-14-4-2-3-13(20)11-14/h2-6,11-12H,7-10H2,1H3,(H,21,22)

SMILES Code

O=C(C1=CN=C(NC2=CC=CC(Cl)=C2)C3=C1N(C)C=C3)N4CCOCC4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 370.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Giblin GM, Billinton A, Briggs M, Brown AJ, Chessell IP, Clayton NM, Eatherton AJ, Goldsmith P, Haslam C, Johnson MR, Mitchell WL, Naylor A, Perboni A, Slingsby BP, Wilson AW. Discovery of 1-[4-(3-chlorophenylamino)-1-methyl-1H-pyrrolo[3,2-c]pyridin-7-yl]-1-morpholin-4- ylmethanone (GSK554418A), a brain penetrant 5-azaindole CB2 agonist for the treatment of chronic pain. J Med Chem. 2009 Oct 8;52(19):5785-8. doi: 10.1021/jm9009857. PubMed PMID: 19743867.