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MedKoo Cat#: 146175 | Name: Cnidilin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cnidilin is a bioactive compound derived from Cnidium monnieri, a plant traditionally used in herbal medicine. It has been studied for its potential applications in enhancing sexual health, improving circulation, and exerting anti-inflammatory effects. Cnidilin works by stimulating the production of nitric oxide, which helps relax blood vessels and improve blood flow, particularly in the pelvic area. Its mechanism also involves modulating inflammatory pathways, providing both vasodilatory and anti-inflammatory benefits that support overall cardiovascular and reproductive health.

Chemical Structure

Cnidilin
Cnidilin
CAS#14348-22-2

Theoretical Analysis

MedKoo Cat#: 146175

Name: Cnidilin

CAS#: 14348-22-2

Chemical Formula: C17H16O5

Exact Mass: 300.0998

Molecular Weight: 300.31

Elemental Analysis: C, 67.99; H, 5.37; O, 26.64

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Cnidilin; Knidilin;
IUPAC/Chemical Name
9-methoxy-4-((3-methylbut-2-en-1-yl)oxy)-7H-furo[3,2-g]chromen-7-one
InChi Key
NNDOCYLWULORAM-UHFFFAOYSA-N
InChi Code
1S/C17H16O5/c1-10(2)6-8-20-14-11-4-5-13(18)22-16(11)17(19-3)15-12(14)7-9-21-15/h4-7,9H,8H2,1-3H3
SMILES Code
COC1=C2OC=CC2=C(OCC=C(C)C)C3=C1OC(=O)C=C3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 300.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Huo H, Jia P, Zhang X, Zhang Z, Yang H, Zhang Q, Shi H, Zhang L. Tentative identification of new metabolites of cnidilin by liquid chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Jul 15;995-996:85-92. doi: 10.1016/j.jchromb.2015.05.002. Epub 2015 Jun 1. PMID: 26038237. 2: Yuan L, Zhang Y, Liao M, Liu Y, Wan C, Zhang L. UHPLC-Q-TOF-MS/MS-based screening and characterization of metabolites of cnidilin in human liver microsomes. Biomed Chromatogr. 2017 Nov;31(11). doi: 10.1002/bmc.3992. Epub 2017 May 21. PMID: 28431455. 3: Zhu H, Liu P, Shi X, Xu H, Ren Y, Wang Q, Zhang L. Determination of cnidilin and its two metabolites in rat plasma by high-performance liquid chromatography- electrospray ionization tandem mass spectrometry. Planta Med. 2013 Jan;79(1):30-6. doi: 10.1055/s-0032-1327983. Epub 2012 Nov 27. PMID: 23188706. 4: Zhu H, Ren Y, Sun Y, Chang L, Cao L, Xu H, Zhang L. Determination of cnidilin and its two metabolites in rat bile and stool after oral administration by HPLC/electrospray ionization tandem mass spectrometry. Biomed Chromatogr. 2013 Apr;27(4):527-34. doi: 10.1002/bmc.2827. Epub 2012 Sep 27. PMID: 23019010. 5: Lili W, Yehong S, Qi Y, Yan H, Jinhui Z, Yan L, Cheng G. In vitro permeability analysis, pharmacokinetic and brain distribution study in mice of imperatorin, isoimperatorin and cnidilin in Radix Angelicae Dahuricae. Fitoterapia. 2013 Mar;85:144-53. doi: 10.1016/j.fitote.2013.01.007. Epub 2013 Jan 23. PMID: 23353658. 6: Bartnik M. Methoxyfuranocoumarins of Natural Origin-Updating Biological Activity Research and Searching for New Directions-A Review. Curr Issues Mol Biol. 2024 Jan 19;46(1):856-883. doi: 10.3390/cimb46010055. PMID: 38275669; PMCID: PMC10813879. 7: Liu X, Li F. Microwave-assisted extraction of bioactive components from Angelica dahurica using the tailor-made natural deep eutectic solvents. Biomed Chromatogr. 2023 Aug;37(8):e5639. doi: 10.1002/bmc.5639. Epub 2023 Apr 18. PMID: 37012641. 8: Zhang Y, Hou M, Yu Y, Xie W, Chang R, Zhang G, Zhang H, Yu H, Chen A. Simultaneous separation and determination of six furanocoumarins in Radix Angelicae dahuricae by CZE with dual CDs system. Anal Biochem. 2022 Oct 15;655:114869. doi: 10.1016/j.ab.2022.114869. Epub 2022 Aug 19. PMID: 35988798. 9: Song PP, Lv Y, Xu ZL, Wang Q, Wang NH. [Chemical constituents of Angelica nitida roots]. Zhong Yao Cai. 2014 Jan;37(1):55-7. Chinese. PMID: 25090703. 10: Chen IS, Chang CT, Sheen WS, Teng CM, Tsai IL, Duh CY, Ko FN. Coumarins and antiplatelet aggregation constituents from Formosan Peucedanum japonicum. Phytochemistry. 1996 Feb;41(2):525-30. doi: 10.1016/0031-9422(95)00625-7. PMID: 8821432. 11: Zaugg J, Eickmeier E, Rueda DC, Hering S, Hamburger M. HPLC-based activity profiling of Angelica pubescens roots for new positive GABAA receptor modulators in Xenopus oocytes. Fitoterapia. 2011 Apr;82(3):434-40. doi: 10.1016/j.fitote.2010.12.001. Epub 2010 Dec 13. PMID: 21147202. 12: Chinou I, Widelski J, Fokialakis N, Magiatis P, Glowniak K. Coumarins from Peucedanum luxurians. Fitoterapia. 2007 Sep;78(6):448-9. doi: 10.1016/j.fitote.2007.04.004. Epub 2007 May 24. PMID: 17582700. 13: Wang CC, Lai JE, Chen LG, Yen KY, Yang LL. Inducible nitric oxide synthase inhibitors of Chinese herbs. Part 2: naturally occurring furanocoumarins. Bioorg Med Chem. 2000 Dec;8(12):2701-7. doi: 10.1016/s0968-0896(00)00200-5. PMID: 11131161. 14: Wang J, Peng L, Shi M, Li C, Zhang Y, Kang W. Spectrum Effect Relationship and Component Knock-Out in Angelica Dahurica Radix by High Performance Liquid Chromatography-Q Exactive Hybrid Quadrupole-Orbitrap Mass Spectrometer. Molecules. 2017 Jul 21;22(7):1231. doi: 10.3390/molecules22071231. PMID: 28754032; PMCID: PMC6152310. 15: Deng R, Zhang J, Luo W, Zhou L, Zheng H, Zhang Y. [Quantitative determination of six coumarins in Angelica dahurica var. formosana by RRLC-UV]. Zhongguo Zhong Yao Za Zhi. 2010 Dec;35(23):3184-7. Chinese. PMID: 21355245. 16: Ashkenazy D, Friedman J, Kashman Y. The furocoumarin composition of Pituranthos triradiatus. Planta Med. 1983 Apr;47(4):218-20. doi: 10.1055/s-2007-969990. PMID: 17404918. 17: Zhao F, Wang S, Wu X, Yu Y, Yue Z, Liu B, Lin S, Zhu C, Yang Y, Shi J. [Non- anthraquinones constituents from the roots of Knoxia valerianoides]. Zhongguo Zhong Yao Za Zhi. 2012 Jul;37(14):2092-9. Chinese. PMID: 23126191. 18: Zhang P, Yang XW. [Studies on chemical constituents in roots and rhizomes of Notopterygium incisum]. Zhongguo Zhong Yao Za Zhi. 2008 Dec;33(24):2918-21. Chinese. PMID: 19294850. 19: Liu YY, Zhang C, Li L, Xiao YQ. [Studies on chemical constituents in roots of Heracleum rapula]. Zhongguo Zhong Yao Za Zhi. 2006 Feb;31(4):309-11. Chinese. PMID: 16706022.

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