Synonym
Ninopterin; 9-Me-PGA; L-Glutamic acid, 9-methylpteroyl-; NSC 107137; NSC-107137; NSC107137;
IUPAC/Chemical Name
(4-((1-(2-amino-4-hydroxypteridin-6-yl)ethyl)amino)benzoyl)-L-glutamic acid
InChi Key
VNZCGWSZJOIBAK-ACGXKRRESA-N
InChi Code
InChI=1S/C20H21N7O6/c1-9(13-8-22-16-15(24-13)18(31)27-20(21)26-16)23-11-4-2-10(3-5-11)17(30)25-12(19(32)33)6-7-14(28)29/h2-5,8-9,12,23H,6-7H2,1H3,(H,25,30)(H,28,29)(H,32,33)(H3,21,22,26,27,31)/t9?,12-/m0/s1
SMILES Code
O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(NC(C2=NC3=C(O)N=C(N)N=C3N=C2)C)C=C1)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
455.43
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Wing YK, Lee S. Methylfolate and psychiatric illness. Br J Psychiatry. 1992 May;160:714-5. PubMed PMID: 1591586.
2: Anderson D, Wilkinson A, Abou-Saleh M, Farrar G, Blair JA. Enhancement of recovery from psychiatric illness by methylfolate. Br J Psychiatry. 1992 Jan;160:130. PubMed PMID: 1510745.
3: Stokstad EL, Okinaka O, Kusano G. Experiments on the biological activities of various fractions of the folic acid antagonist "X-methyl" folic acid. Arch Biochem Biophys. 1986 Nov 15;251(1):260-5. PubMed PMID: 3789733.
4: Schmidt RR, Slobodian SA, Chepenik KP, Cotler JM. Effect of a synthetic folic acid analogue, 9-methyl-pteroylglutamic acid, on fetal chondrogenesis: ultrastructural observations. Biol Neonate. 1983;43(5-6):281-6. PubMed PMID: 6871296.
5: Schmidt RR, Abbott K, Cotler JM. In vitro effects of the teratogen and folic acid antagonist, 9-methyl pteroylglutamic acid, on glycosaminoglycan accumulation in fetal rat limbs. Teratology. 1982 Aug;26(1):53-7. PubMed PMID: 7135258.
6: Schmidt RR, Abbott PK, Cotler JM. 9-methyl pteroylglutamic acid, a synthetic analogue of folic acid: its effects on hexosamine levels in fetal rat limbs and other fetal tissues. Biol Neonate. 1982;41(1-2):52-6. PubMed PMID: 7199941.
7: Waxman S, Schreiber C, Waxman S. Evaluation of X-methyl folate preparations as possible folic acid antagonists. Chemotherapy. 1982;28(5):402-9. PubMed PMID: 7140422.
8: MORGAN HR. Factors related to the growth of psittacosis virus (strain 6BC). I. Pteroylglutamic acid, vitamin B12, and citrovorum factor. J Exp Med. 1952 Mar;95(3):269-76. PubMed PMID: 14927792; PubMed Central PMCID: PMC2212073.
