Quercetagetin | CAS#90-18-6 | flavonoid

MedKoo Cat#: 146154 | Name: Quercetagetin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Quercetagetin is a flavonoid compound found in various plants, known for its potent antioxidant, anti-inflammatory, and anticancer properties. It exerts its effects by scavenging free radicals and inhibiting oxidative stress, which plays a key role in the development of chronic diseases. Quercetagetin is applied in the fields of pharmacology and nutrition, often studied for its potential therapeutic effects, including reducing inflammation and preventing cancer cell growth. Its mechanism involves modulation of signaling pathways related to inflammation, cell proliferation, and apoptosis, contributing to its protective and therapeutic actions.

Chemical Structure

Quercetagetin

CAS#90-18-6

Theoretical Analysis

MedKoo Cat#: 146154

Name: Quercetagetin

CAS#: 90-18-6

Chemical Formula: C15H10O8

Exact Mass: 318.0376

Molecular Weight: 318.24

Elemental Analysis: C, 56.61; H, 3.17; O, 40.22

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Quercetagetin;

IUPAC/Chemical Name

2-(3,4-dihydroxyphenyl)-3,5,6,7-tetrahydroxy-4H-chromen-4-one

InChi Key

ZVOLCUVKHLEPEV-UHFFFAOYSA-N

InChi Code

1S/C15H10O8/c16-6-2-1-5(3-7(6)17)15-14(22)13(21)10-9(23-15)4-8(18)11(19)12(10)20/h1-4,16-20,22H

SMILES Code

OC1=CC=C(C=C1O)C2=C(O)C(=O)C3=C(O2)C=C(O)C(O)=C3O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 318.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Wang H, Yuan T, Wang J, Li D, Lee WY, Li Z, Sun S. Quercetagetin alleviates inflammatory osteoclastogenesis and collagen antibody-induced arthritis via Nrf2 signaling and Pten/AKT/Nfatc1 axis. Arthritis Res Ther. 2025 Mar 8;27(1):54. doi: 10.1186/s13075-025-03522-x. PMID: 40057805; PMCID: PMC11889843. 2: Wu F, Wang F, Tang Z, Yang X, Liu Y, Zhao M, Liu S, Han S, Zhang Z, Chen B. Quercetagetin alleviates zearalenone-induced liver injury in rabbits through Keap1/Nrf2/ARE signaling pathway. Front Pharmacol. 2023 Oct 3;14:1271384. doi: 10.3389/fphar.2023.1271384. PMID: 37854718; PMCID: PMC10579610. 3: Taylor AO, Wong E. Quercetagetin 3,6-dimethyl ether. Tetrahedron Lett. 1965 Oct;(41):3675-8. doi: 10.1016/s0040-4039(01)89154-1. PMID: 5842461. 4: Liang F. Inhibition mechanism investigation of quercetagetin as a potential tyrosinase inhibitor. Front Chem. 2024 Jun 3;12:1411801. doi: 10.3389/fchem.2024.1411801. PMID: 38894729; PMCID: PMC11184945. 5: Parejo I, Bastida J, Viladomat F, Codina C. Acylated quercetagetin glycosides with antioxidant activity from Tagetes maxima. Phytochemistry. 2005 Oct;66(19):2356-62. doi: 10.1016/j.phytochem.2005.07.004. PMID: 16168446. 6: Mustafa T, Khan I, Iqbal H, Usman S, Naeem N, Faizi S, Salim A. Rutin and quercetagetin enhance the regeneration potential of young and aging bone marrow- derived mesenchymal stem cells in the rat infarcted myocardium. Mol Cell Biochem. 2023 Aug;478(8):1759-1770. doi: 10.1007/s11010-022-04628-5. Epub 2022 Dec 25. PMID: 36566485. 7: Kang GJ, Han SC, Kang NJ, Koo DH, Park DB, Eun SY, Kang HK, Yoo ES. Quercetagetin inhibits macrophage-derived chemokine in HaCaT human keratinocytes via the regulation of signal transducer and activator of transcription 1, suppressor of cytokine signalling 1 and transforming growth factor-β1. Br J Dermatol. 2014 Sep;171(3):512-23. doi: 10.1111/bjd.12938. Epub 2014 Aug 22. PMID: 24602010. 8: Xu H, Liu X, Yan Q, Yuan F, Gao Y. A novel copigment of quercetagetin for stabilization of grape skin anthocyanins. Food Chem. 2015 Jan 1;166:50-55. doi: 10.1016/j.foodchem.2014.05.125. Epub 2014 Jun 6. PMID: 25053027. 9: Sahin E, Orhan C, Sahin N, Padigaru M, Morde A, Lal M, Dhavan N, Erten F, Bilgic AA, Ozercan IH, Sahin K. Lutein/Zeaxanthin Isomers and Quercetagetin Combination Safeguards the Retina from Photo-Oxidative Damage by Modulating Neuroplasticity Markers and the Nrf2 Pathway. Pharmaceuticals (Basel). 2023 Nov 1;16(11):1543. doi: 10.3390/ph16111543. PMID: 38004409; PMCID: PMC10675275. 10: Zhang H, Wang J, Sun X, Zhang Y, Dong M, Wang X, Li L, Wang L. Fabrication and Characterization of Quercetagetin-Loaded Nanoparticles Based on Shellac and Quaternized Chitosan: Improvement of Encapsulation Efficiency and Acid and Storage Stabilities. J Agric Food Chem. 2021 Dec 29;69(51):15670-15680. doi: 10.1021/acs.jafc.1c01830. Epub 2021 Dec 18. PMID: 34923817. 11: Alvarado-Sansininea JJ, Sánchez-Sánchez L, López-Muñoz H, Escobar ML, Flores-Guzmán F, Tavera-Hernández R, Jiménez-Estrada M. Quercetagetin and Patuletin: Antiproliferative, Necrotic and Apoptotic Activity in Tumor Cell Lines. Molecules. 2018 Oct 9;23(10):2579. doi: 10.3390/molecules23102579. PMID: 30304821; PMCID: PMC6222523. 12: Zhuo Y, Liang Y, Xu D, McClements DJ, Wang S, Li Q, Han Y, Liu F, Chen S. Improvement of physicochemical stability and digestive properties of quercetagetin using zein-chondroitin sulfate particles prepared by antisolvent co-precipitation. Int J Biol Macromol. 2023 Jul 1;242(Pt 4):125109. doi: 10.1016/j.ijbiomac.2023.125109. Epub 2023 May 30. PMID: 37257529. 13: Chen S, Sun C, Wang Y, Han Y, Dai L, Abliz A, Gao Y. Quercetagetin-Loaded Composite Nanoparticles Based on Zein and Hyaluronic Acid: Formation, Characterization, and Physicochemical Stability. J Agric Food Chem. 2018 Jul 18;66(28):7441-7450. doi: 10.1021/acs.jafc.8b01046. Epub 2018 Jun 25. PMID: 29897751. 14: Baek S, Kang NJ, Popowicz GM, Arciniega M, Jung SK, Byun S, Song NR, Heo YS, Kim BY, Lee HJ, Holak TA, Augustin M, Bode AM, Huber R, Dong Z, Lee KW. Structural and functional analysis of the natural JNK1 inhibitor quercetagetin. J Mol Biol. 2013 Jan 23;425(2):411-23. doi: 10.1016/j.jmb.2012.10.019. Epub 2012 Nov 8. PMID: 23142567; PMCID: PMC3540140. 15: Quan T, Tao Y, Wang J, Liu S, Yang L, Wang L, Liu Q, Yang Y, Zou Y, Tian M, Wang D, Gao D. Hydroxyl-riched covalent organic framework for solid-phase microextraction of flavonoids aglycones or their metabolites in mice's plasma: Luteolin and quercetagetin as examples. J Chromatogr A. 2022 Oct 11;1681:463478. doi: 10.1016/j.chroma.2022.463478. Epub 2022 Sep 6. PMID: 36099693. 16: Sun C, Wei Y, Li R, Dai L, Gao Y. Quercetagetin-Loaded Zein-Propylene Glycol Alginate Ternary Composite Particles Induced by Calcium Ions: Structure Characterization and Formation Mechanism. J Agric Food Chem. 2017 May 17;65(19):3934-3945. doi: 10.1021/acs.jafc.7b00921. Epub 2017 May 5. PMID: 28460525. 17: Li K, Ge X, Liu W, Huang L, Lv X, Tang Y, He Z, Yang Y, Chen M, Zeng J, Cheng P. Synthesis and Biological Evaluation of Quercetagetin Derivatives as the Inhibitors of Mcl-1 and Bcl-2 Against Leukemia. Int J Mol Sci. 2025 Mar 18;26(6):2727. doi: 10.3390/ijms26062727. PMID: 40141366; PMCID: PMC11943384. 18: Ma RT, Shi YP. Magnetic molecularly imprinted polymer for the selective extraction of quercetagetin from Calendula officinalis extract. Talanta. 2015 Mar;134:650-656. doi: 10.1016/j.talanta.2014.12.003. Epub 2014 Dec 15. PMID: 25618718. 19: Wu F, Wang H, Li S, Wei Z, Han S, Chen B. Effects of dietary supplementation with quercetagetin on nutrient digestibility, intestinal morphology, immunity, and antioxidant capacity of broilers. Front Vet Sci. 2022 Dec 23;9:1060140. doi: 10.3389/fvets.2022.1060140. PMID: 36619942; PMCID: PMC9816998. 20: Wang W, Xu H, Chen H, Tai K, Liu F, Gao Y. In vitro antioxidant, anti- diabetic and antilipemic potentials of quercetagetin extracted from marigold (Tagetes erecta L.) inflorescence residues. J Food Sci Technol. 2016 Jun;53(6):2614-24. doi: 10.1007/s13197-016-2228-6. Epub 2016 Jun 25. PMID: 27478217; PMCID: PMC4951414.