ATN-453 is a biotinylated analogue of ATN-161 that had been shown to retain the full binding activity of ATN-161. ATN-453 is a derivative of ATN-161, a peptide that binds to integrins α5β1 and αvβ3, playing a role in tumor growth and metastasis. ATN-161's sequence is Ac-PHSCN-NH₂, where "Ac" denotes acetylation at the N-terminus, and "NH₂" indicates amidation at the C-terminus. ATN-453 extends this sequence by adding a biotinylated glycine-glycine-lysine (GGK) motif at the C-terminus, resulting in Ac-PHSCNGGK-biotin. This modification allows ATN-453 to bind to integrins α5β1 and αvβ3, facilitating the study of integrin-related processes in cancer research.
MedKoo Cat#: 556388
Name: ATN-453
CAS#: 729595-08-8
Chemical Formula: C43H67N15O13S2
Exact Mass: 1065.4484
Molecular Weight: 1066.22
Elemental Analysis: C, 48.44; H, 6.33; N, 19.71; O, 19.51; S, 6.01
The following data is based on the product molecular weight 1,066.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
