Gemcitabine monophosphate disodium salt, also called GemMP, is a monophosphate derivative of Gemcitabine. Gemcitabine (Gem) is a deoxycytidine analog that is effective against pancreatic cancer and other malignancies following conversion to the 5'-O-mono-, di- and tri-phosphate forms. GemMP decreased tumor cell growth at concentrations ranging from 1 to 50 nM. GemMP is a potent cytotoxic agent that serves to induce apoptosis in association with increased Fas expression in cultured thyroid cancer cell lines. (Anticancer Res. 2000 Sep-Oct;20(5A):2915-22). Note: Current batch has purity ~ 90%.
MedKoo Cat#: 406576
Name: Gemcitabine monophosphate disodium salt
CAS#: 1638288-31-9 (disodium)
Chemical Formula: C9H12F2N3Na2O8P
Exact Mass: 0.0000
Molecular Weight: 405.16
Elemental Analysis: C, 26.68; H, 2.99; F, 9.38; N, 10.37; Na, 11.35; O, 31.59; P, 7.64
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10.0 | 24.68 |
The following data is based on the product molecular weight 405.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
