MedKoo Cat#: 128688 | Name: E10i-494
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

E10i-494 is an ionizable cationic branched endosomal disruptor (BEND) lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro.

Chemical Structure

E10i-494
E10i-494
CAS#3031773-77-7

Theoretical Analysis

MedKoo Cat#: 128688

Name: E10i-494

CAS#: 3031773-77-7

Chemical Formula: C89H183N5O7

Exact Mass: 1434.4118

Molecular Weight: 1435.47

Elemental Analysis: C, 74.47; H, 12.85; N, 4.88; O, 7.80

Price and Availability

Size Price Availability Quantity
1mg USD 350.00 2 Weeks
5mg USD 750.00 2 Weeks
10mg USD 1,150.00 2 Weeks
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Related CAS #
No Data
Synonym
E10i-494; E10i494l; E10i 494
IUPAC/Chemical Name
1,1'-((2-(2-(4-(2-((2-(2-(bis(2-hydroxy-13-methyltetradecyl)amino)ethoxy)ethyl)(2-hydroxy-13-methyltetradecyl)amino)ethyl)piperazin-1-yl)ethoxy)ethyl)azanediyl)bis(13-methyltetradecan-2-ol)
InChi Key
QKCHHRREJZYEPH-UHFFFAOYSA-N
InChi Code
InChI=1S/C89H183N5O7/c1-80(2)51-41-31-21-11-16-26-36-46-56-85(95)75-92(68-72-101-74-70-94(78-88(98)59-49-39-29-19-14-24-34-44-54-83(7)8)79-89(99)60-50-40-30-20-15-25-35-45-55-84(9)10)66-65-90-61-63-91(64-62-90)67-71-100-73-69-93(76-86(96)57-47-37-27-17-12-22-32-42-52-81(3)4)77-87(97)58-48-38-28-18-13-23-33-43-53-82(5)6/h80-89,95-99H,11-79H2,1-10H3
SMILES Code
OC(CCCCCCCCCCC(C)C)CN(CCOCCN(CCN(CC1)CCN1CCOCCN(CC(CCCCCCCCCCC(C)C)O)CC(CCCCCCCCCCC(C)C)O)CC(O)CCCCCCCCCCC(C)C)CC(O)CCCCCCCCCCC(C)C
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,435.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Padilla, M.S., Mrksich, K., Wang, Y., et al. Branched endosomal disruptor (BEND) lipids mediate delivery of mRNA and CRISPR-Cas9 ribonucleoprotein complex for hepatic gene editing and T cell engineering. Nat. Commun. 16(1), 996 (2025).