XW-032 is a Apo-IDO1 Inhibitor. XW-001 through structure-based virtual screening, followed by an iterative optimization process that led to the development of XW-032. XW-032 exhibited remarkable in vitro inhibitory activity against apo-IDO1 (IC50 = 21 ± 5 nM) through a pharmacophore-guided structural simplification approach. Notably, XW-032 (TGI = 63%) exhibited potent in vivo antitumor efficacy in the CT26 syngeneic mouse model, highlighting the benefits of apo-IDO1 inhibitors for tumor immunotherapy.
MedKoo Cat#: 128599
Name: XW-032
CAS#: N/A
Chemical Formula: C21H18F2N2O
Exact Mass: 352.1387
Molecular Weight: 352.38
Elemental Analysis: C, 71.58; H, 5.15; F, 10.78; N, 7.95; O, 4.54
The following data is based on the product molecular weight 352.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
