JSF-4536 | Mycobacterium tuberculosis inhibitor

MedKoo Cat#: 128594 | Name: JSF-4536

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JSF-4536 is a Mycobacterium tuberculosis inhibitor. JSF-4898 demonstrated significantly improved biological profiles, notably offering submicromolar MIC values versus M. tuberculosis and promising values characterizing the mouse liver microsome stability, aqueous solubility, and mousepharmacokinetic profile.

Chemical Structure

JSF-4536

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128594

Name: JSF-4536

CAS#: N/A

Chemical Formula: C22H22ClFN2O3

Exact Mass: 416.1303

Molecular Weight: 416.88

Elemental Analysis: C, 63.39; H, 5.32; Cl, 8.50; F, 4.56; N, 6.72; O, 11.51

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

JSF-4536; JSF4536; JSF 4536

IUPAC/Chemical Name

5'-(2-chloro-4-fluorobenzamido)-2'-methoxy-N-methyl-2,3,4,5-tetrahydro-[1,1'-biphenyl]-4-carboxamide

InChi Key

DHNQOLNBPUXNSM-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H22ClFN2O3/c1-25-21(27)14-5-3-13(4-6-14)18-12-16(8-10-20(18)29-2)26-22(28)17-9-7-15(24)11-19(17)23/h3,7-12,14H,4-6H2,1-2H3,(H,25,27)(H,26,28)

SMILES Code

FC1=CC=C(C(NC2=CC(C3=CCC(C(NC)=O)CC3)=C(OC)C=C2)=O)C(Cl)=C1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 416.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Sharma P, Jiang Q, Li SG, Ocke E, Tsotetsi K, Sukheja P, Singh P, Suryavanshi S, Morrison E, Thadkapally S, Russo R, Penalva-Lopez S, Cangialosi J, Sharma V, Johnson K, Sarathy JP, Nelson AM, Park S, Zimmerman MD, Alland D, Kumar P, Freundlich JS. Evolution of Small Molecule Inhibitors of Mycobacterium tuberculosis Menaquinone Biosynthesis. J Med Chem. 2025 Mar 4. doi: 10.1021/acs.jmedchem.4c03156. Epub ahead of print. PMID: 40035499.