Synonym
GV150013; GV 150013; GV-150013.
IUPAC/Chemical Name
1-[(3R)-1-(1-adamantylmethyl)-2,4-dioxo-5-phenyl-1,5-benzodiazepin-3-yl]-3-phenylurea
InChi Key
RZERRLOTRSJIAW-NEPGVILWSA-N
InChi Code
InChI=1S/C33H34N4O3/c38-30-29(35-32(40)34-25-9-3-1-4-10-25)31(39)37(26-11-5-2-6-12-26)28-14-8-7-13-27(28)36(30)21-33-18-22-15-23(19-33)17-24(16-22)20-33/h1-14,22-24,29H,15-21H2,(H2,34,35,40)/t22?,23?,24?,29-,33?/m1/s1
SMILES Code
O=C(NC1=CC=CC=C1)N[C@@H]2C(N(CC34CC5CC(C4)CC(C5)C3)C6=CC=CC=C6N(C7=CC=CC=C7)C2=O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
534.66
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Fornai M, Colucci R, Antonioli L, Crema F, Buccianti P, Chiarugi M, Baschiera F, Ghisu N, Tuccori M, Blandizzi C, Del Tacca M. Cholecystokinin CCK2 receptors mediate the peptide's inhibitory actions on the contractile activity of human distal colon via the nitric oxide pathway. Br J Pharmacol. 2007 Aug;151(8):1246-53. PubMed PMID: 17572695; PubMed Central PMCID: PMC2189827.
2: Fornai M, Colucci R, Antonioli L, Baschiera F, Ghisu N, Tuccori M, Gori G, Blandizzi C, Del Tacca M. CCK2 receptors mediate inhibitory effects of cholecystokinin on the motor activity of guinea-pig distal colon. Eur J Pharmacol. 2007 Feb 28;557(2-3):212-20. PubMed PMID: 17208221.
