GHN105 is an orally bioavailable covalent STING inhibitor. GHN105 dose-dependently inhibited cGAS-STING signaling and type I interferon responses in cells and in vivo. Moreover, orally administered GHN105 exhibited on-target engagement in vivo and markedly reversed key pathological features in a delayed treatment of the acute colitis mouse model.
MedKoo Cat#: 128579
Name: GHN105
CAS#: N/A
Chemical Formula: C42H58N2O14
Exact Mass: 814.3888
Molecular Weight: 814.93
Elemental Analysis: C, 61.90; H, 7.17; N, 3.44; O, 27.49
The following data is based on the product molecular weight 814.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |