MedKoo Cat#: 128579 | Name: GHN105

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GHN105 is an orally bioavailable covalent STING inhibitor. GHN105 dose-dependently inhibited cGAS-STING signaling and type I interferon responses in cells and in vivo. Moreover, orally administered GHN105 exhibited on-target engagement in vivo and markedly reversed key pathological features in a delayed treatment of the acute colitis mouse model.

Chemical Structure

GHN105
GHN105
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128579

Name: GHN105

CAS#: N/A

Chemical Formula: C42H58N2O14

Exact Mass: 814.3888

Molecular Weight: 814.93

Elemental Analysis: C, 61.90; H, 7.17; N, 3.44; O, 27.49

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
GHN105; GHN-105; GHN 105
IUPAC/Chemical Name
(2aS,7S,8R,8aR,9S,11S,12R,12aS,13S,13aS,14aR,E)-7-(butyryloxy)-8a,12,14a-trimethyl-1-oxo-11-((3-(piperidin-1-yl)propanoyl)oxy)-5-((E)-((prop-2-yn-1-yloxy)imino)methyl)-1,2a,3,6,7,8,8a,9,10,11,12,12a,13,14a-tetradecahydrobenzo[4,5]cycloundeca[1,2-b]oxireno[2,3-c]furan-8,9,13-triyl triacetate
InChi Key
XWQLNOPRNMKHHS-JURITHPXSA-N
InChi Code
InChI=1S/C42H58N2O14/c1-9-14-34(48)56-31-22-29(24-43-51-21-10-2)15-16-32-42(41(8,58-42)39(50)57-32)38(54-28(6)47)36-25(3)30(55-35(49)17-20-44-18-12-11-13-19-44)23-33(52-26(4)45)40(36,7)37(31)53-27(5)46/h2,15,24-25,30-33,36-38H,9,11-14,16-23H2,1,3-8H3/b29-15+,43-24+/t25-,30-,31-,32-,33?,36+,37?,38?,40-,41-,42-/m0/s1
SMILES Code
C[C@H]([C@@]1([H])[C@@](C)([C@@H](OC(C)=O)[C@@H](OC(CCC)=O)CC(/C=N/OCC#C)=C\C[C@H]2[C@]([C@]3(C)C(O2)=O)(O3)[C@H]1OC(C)=O)[C@@H](OC(C)=O)C4)[C@H]4OC(CCN5CCCCC5)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 814.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Niu GH, Hsiao WC, Lee PH, Zheng LG, Yang YS, Huang WC, Hsieh CC, Chiu TY, Wang JY, Chen CP, Huang CL, You MS, Kuo YP, Wang CM, Wen ZH, Yu GY, Chen CT, Chi YH, Tung CW, Hsu SC, Yeh TK, Sung PJ, Zhang MM, Tsou LK. Orally Bioavailable and Site-Selective Covalent STING Inhibitor Derived from a Macrocyclic Marine Diterpenoid. J Med Chem. 2025 Feb 27. doi: 10.1021/acs.jmedchem.4c02665. Epub ahead of print. PMID: 40014799.