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MedKoo Cat#: 584154 | Name: Tralomethrin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tralomethrin is an agricultural chemical used as a pyrethroid insecticide. It kills by modifying the gating kinetics of the sodium channels in neurons, increasing the length of time the channel remains open after a stimulus, thereby depolarizing the neuron for a longer period of time. This leads to uncontrolled spasms, paralysis, and eventual death.

Chemical Structure

Tralomethrin
Tralomethrin
CAS#66841-25-6

Theoretical Analysis

MedKoo Cat#: 584154

Name: Tralomethrin

CAS#: 66841-25-6

Chemical Formula: C22H19Br4NO3

Exact Mass: 660.8098

Molecular Weight: 665.01

Elemental Analysis: C, 39.73; H, 2.88; Br, 48.06; N, 2.11; O, 7.22

Price and Availability

Size Price Availability Quantity
50mg USD 550.00 2 Weeks
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Synonym
Tralomethrin; EPA Pesticide Chemical Code 121501; SAGA; Scout; HAG 107; HAG-107; HAG107
IUPAC/Chemical Name
Cyclopropanecarboxylic acid, 2,2-dimethyl-3-(1,2,2,2-tetrabromoethyl)-, cyano(3-phenoxyphenyl)methyl ester
InChi Key
YWSCPYYRJXKUDB-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H19Br4NO3/c1-21(2)17(19(23)22(24,25)26)18(21)20(28)30-16(12-27)13-7-6-10-15(11-13)29-14-8-4-3-5-9-14/h3-11,16-19H,1-2H3
SMILES Code
O=C(C1C(C)(C)C1C(Br)C(Br)(Br)Br)OC(C#N)C2=CC=CC(OC3=CC=CC=C3)=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 665.01 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Guo S, Wu Y, Li W, Xiao P. Tralomethrin causes cardiovascular toxicity in zebrafish (Danio rerio) embryos. Environ Toxicol. 2023 Nov;38(11):2761-2771. doi: 10.1002/tox.23911. Epub 2023 Jul 20. PMID: 37471628. 2: Brown LD, Narahashi T. Activity of tralomethrin to modify the nerve membrane sodium channel. Toxicol Appl Pharmacol. 1987 Jul;89(3):305-13. doi: 10.1016/0041-008x(87)90150-5. PMID: 2440147. 3: Valverde A, Aguilera A, Rodríguez M, Boulaid M. What are we determining using gas chromatographic multiresidue methods: tralomethrin or deltamethrin? J Chromatogr A. 2002 Jan 11;943(1):101-11. doi: 10.1016/s0021-9673(01)01414-5. PMID: 11820271. 4: Boulaid M, Aguilera A, Camacho F, Soussi M, Valverde A. Effect of household processing and unit-to-unit variability of pyrifenox, pyridaben, and tralomethrin residues in tomatoes. J Agric Food Chem. 2005 May 18;53(10):4054-8. doi: 10.1021/jf040455y. PMID: 15884838. 5: Valverde A, Aguilera A, Rodríguez M, Boulaid M, Soussi-El Begrani M. Pesticide residue levels in peppers grown in a greenhouse after multiple applications of pyridaben and tralomethrin. J Agric Food Chem. 2002 Dec 4;50(25):7303-7. doi: 10.1021/jf0205209. PMID: 12452649. 6: Amalraj DD, Vasuki V, Velayudhan R. Tralomethrin (OMS-3048), a new synthetic pyrethroid against vector mosquitoes. Indian J Malariol. 1991 Sep;28(3):141-5. PMID: 1688021. 7: Laskowski DA. Physical and chemical properties of pyrethroids. Rev Environ Contam Toxicol. 2002;174:49-170. doi: 10.1007/978-1-4757-4260-2_3. PMID: 12132343. 8: Takatsuki S, Nemoto S, Sasaki K, Toyoda M. [Specific determination of deltamethrin and tralomethrin by preparative HPLC and GC-ECD]. Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku. 1997;(115):135-9. Japanese. PMID: 9641828. 9: Erstfeld KM. Environmental fate of synthetic pyrethroids during spray drift and field runoff treatments in aquatic microcosms. Chemosphere. 1999 Oct;39(10):1737-69. doi: 10.1016/s0045-6535(99)00064-8. PMID: 10520490. 10: Solomon KR, Giddings JM, Maund SJ. Probabilistic risk assessment of cotton pyrethroids: I. Distributional analyses of laboratory aquatic toxicity data. Environ Toxicol Chem. 2001 Mar;20(3):652-9. doi: 10.1897/1551-5028(2001)020<0652:praocp>2.0.co;2. PMID: 11349868. 11: Cole LM, Ruzo LO, Wood EJ, Casida JE. Pyrethroid metabolism: comparative fate in rats of tralomethrin, tralocythrin, deltamethrin, and (1R, alpha S)-cis- cypermethrin. J Agric Food Chem. 1982 Jul-Aug;30(4):631-6. doi: 10.1021/jf00112a003. PMID: 6811643. 12: Hue B, Mony L. Actions of deltamethrin and tralomethrin on cholinergic synaptic transmission in the central nervous system of the cockroach (Periplaneta americana). Comp Biochem Physiol C Comp Pharmacol Toxicol. 1987;86(2):349-52. doi: 10.1016/0742-8413(87)90092-2. PMID: 2882930. 13: Ishibashi M, Ando T, Sakai M, Matsubara A, Uchikata T, Fukusaki E, Bamba T. High-throughput simultaneous analysis of pesticides by supercritical fluid chromatography/tandem mass spectrometry. J Chromatogr A. 2012 Nov 30;1266:143-8. doi: 10.1016/j.chroma.2012.09.067. Epub 2012 Sep 28. PMID: 23102524. 14: Lemke LA, Koehler PG, Patterson RS. Susceptibility of the cat flea (Siphonaptera: Pulicidae) to pyrethroids. J Econ Entomol. 1989 Jun;82(3):839-41. doi: 10.1093/jee/82.3.839. PMID: 2754097. 15: Hladik ML, Kuivila KM. Pyrethroid insecticides in bed sediments from urban and agricultural streams across the United States. J Environ Monit. 2012 Jul;14(7):1838-45. doi: 10.1039/c2em10946h. Epub 2012 Mar 15. PMID: 22418650. 16: Feo ML, Eljarrat E, Barceló D. A rapid and sensitive analytical method for the determination of 14 pyrethroids in water samples. J Chromatogr A. 2010 Apr 9;1217(15):2248-53. doi: 10.1016/j.chroma.2010.02.018. Epub 2010 Feb 16. PMID: 20206936. 17: Marshall S, Gennings C, Teuschler LK, Stork LG, Tornero-Velez R, Crofton KM, Rice GE. An empirical approach to sufficient similarity: combining exposure data and mixtures toxicology data. Risk Anal. 2013 Sep;33(9):1582-95. doi: 10.1111/risa.12015. Epub 2013 Feb 11. PMID: 23398277; PMCID: PMC3776008. 18: Di Muccio A, Pelosi P, Barbini DA, Generali T, Ausili A, Vergori F. Selective extraction of pyrethroid pesticide residues from milk by solid-matrix dispersion. J Chromatogr A. 1997 Mar 21;765(1):51-60. doi: 10.1016/s0021-9673(96)01005-9. PMID: 9129301. 19: Atkinson TH, Wadleigh RW, Koehler PG, Patterson RS. Pyrethroid resistance and synergism in a field strain of the German cockroach (Dictyoptera: Blattellidae). J Econ Entomol. 1991 Aug;84(4):1247-50. doi: 10.1093/jee/84.4.1247. PMID: 1842795. 20: Wadleigh RW, Koehler PG, Preisler HK, Patterson RS, Robertson JL. Effect of temperature on the toxicities of ten pyrethroids to German cockroach (Dictyoptera: Blattellidae). J Econ Entomol. 1991 Oct;84(5):1433-6. doi: 10.1093/jee/84.5.1433. PMID: 1744295.