Pydiflumetofen | CAS#1228284-64-7 | fungicide

MedKoo Cat#: 146003 | Name: Pydiflumetofen

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pydiflumetofen is a fungicide belonging to the group of isopropanolamine derivatives, primarily used in agricultural settings to control fungal diseases in crops. Its mechanism of action involves inhibiting the mitochondrial respiration of fungi by targeting the cytochrome bc1 complex (complex III), which is crucial for energy production in fungal cells. This inhibition disrupts the energy metabolism of the fungi, leading to cell death and preventing the spread of fungal infections. Pydiflumetofen is effective against a wide range of plant pathogens, making it valuable for protecting crops such as fruits, vegetables, and cereals from fungal diseases.

Chemical Structure

Pydiflumetofen

CAS#1228284-64-7

Theoretical Analysis

MedKoo Cat#: 146003

Name: Pydiflumetofen

CAS#: 1228284-64-7

Chemical Formula: C16H16Cl3F2N3O2

Exact Mass: 425.0300

Molecular Weight: 426.67

Elemental Analysis: C, 45.04; H, 3.78; Cl, 24.93; F, 8.91; N, 9.85; O, 7.50

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Pydiflumetofen;

IUPAC/Chemical Name

3-(difluoromethyl)-N-methoxy-1-methyl-N-(1-(2,4,6-trichlorophenyl)propan-2-yl)-1H-pyrazole-4-carboxamide

InChi Key

DGOAXBPOVUPPEB-UHFFFAOYSA-N

InChi Code

1S/C16H16Cl3F2N3O2/c1-8(4-10-12(18)5-9(17)6-13(10)19)24(26-3)16(25)11-7-23(2)22-14(11)15(20)21/h5-8,15H,4H2,1-3H3

SMILES Code

CON(C(C)CC1=C(Cl)C=C(Cl)C=C1Cl)C(=O)C2=CN(C)N=C2C(F)F

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 426.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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Dissipation and Dietary Risk Assessment of Pydiflumetofen Residues in Soybean. Molecules. 2022 Dec 2;27(23):8465. doi: 10.3390/molecules27238465. PMID: 36500554; PMCID: PMC9738132. 4: Di S, Cang T, Liu Z, Xie Y, Zhao H, Qi P, Wang Z, Xu H, Wang X. Comprehensive evaluation of chiral pydiflumetofen from the perspective of reducing environmental risks. Sci Total Environ. 2022 Jun 20;826:154033. doi: 10.1016/j.scitotenv.2022.154033. Epub 2022 Feb 19. PMID: 35192824. 5: Zhou F, Cui YX, Zhou YD, Duan ST, Wang ZY, Xia ZH, Hu HY, Liu RQ, Li CW. Baseline Pydiflumetofen Sensitivity of Fusarium pseudograminearum Isolates Collected from Henan, China, and Potential Resistance Mechanisms. Plant Dis. 2023 Aug;107(8):2417-2423. doi: 10.1094/PDIS-08-22-1852-RE. Epub 2023 Aug 11. PMID: 36691280. 6: Edwards SG. Pydiflumetofen Co-Formulated with Prothioconazole: A Novel Fungicide for Fusarium Head Blight and Deoxynivalenol Control. Toxins (Basel). 2022 Jan 3;14(1):34. doi: 10.3390/toxins14010034. PMID: 35051011; PMCID: PMC8778507. 7: Bian C, Wang L, Cui Z, Dong Z, Shi X, Li Y, Li B. Adsorption-desorption and transport behavior of pydiflumetofen in eight different types of soil. Ecotoxicol Environ Saf. 2022 Apr 1;234:113378. doi: 10.1016/j.ecoenv.2022.113378. Epub 2022 Mar 4. PMID: 35255252. 8: Shi X, Xie G, Zhang W, Yu A. Assessment of the Hydrolysis of Pydiflumetofen and Its Degradation Characteristics in Agricultural Soils. Molecules. 2023 May 23;28(11):4282. doi: 10.3390/molecules28114282. PMID: 37298758; PMCID: PMC10254653. 9: European Food Safety Authority (EFSA); Álvarez F, Arena M, Auteri D, Leite SB, Binaglia M, Castoldi AF, Chiusolo A, Colagiorgi A, Colas M, Crivellente F, De Lentdecker C, De Magistris I, Egsmose M, Fait G, Ferilli F, Gouliarmou V, Halling K, Nogareda LH, Ippolito A, Istace F, Jarrah S, Kardassi D, Kienzler A, Lanzoni A, Lava R, Leuschner R, Linguadoca A, Louisse J, Lythgo C, Magrans O, Mangas I, Mioč A, Miron I, Molnar T, Padovani L, Padricello V, Panzarea M, Parra Morte JM, Rizzuto S, Romac A, Rortais A, Santos M, Serafimova R, Sharp R, Szentes C, Terron A, Theobald A, Tiramani M, Vianello G, Villamar-Bouza L. Updated peer review of the pesticide risk assessment of the active substance pydiflumetofen. EFSA J. 2024 Jan 29;22(1):e8559. doi: 10.2903/j.efsa.2024.8559. PMID: 38288395; PMCID: PMC10823393. 10: Mao X, Wu Z, Bi C, Wang J, Zhao F, Gao J, Hou Y, Zhou M. Molecular and Biochemical Characterization of Pydiflumetofen-Resistant Mutants of Didymella bryoniae. J Agric Food Chem. 2020 Aug 26;68(34):9120-9130. doi: 10.1021/acs.jafc.0c03690. Epub 2020 Aug 11. PMID: 32806116. 11: Zhou F, Cui YX, Ma YH, Wang JY, Hu HY, Li SW, Zhang FL, Li CW. Investigating the Potential Mechanism of Pydiflumetofen Resistance in Sclerotinia sclerotiorum. Plant Dis. 2021 Nov;105(11):3580-3585. doi: 10.1094/PDIS-03-21-0455-RE. Epub 2021 Nov 18. PMID: 33934629. 12: Li X, Gao X, Hu S, Hao X, Li G, Chen Y, Liu Z, Li Y, Miao J, Gu B, Liu X. Resistance to pydiflumetofen in Botrytis cinerea: risk assessment and detection of point mutations in sdh genes that confer resistance. Pest Manag Sci. 2022 Apr;78(4):1448-1456. doi: 10.1002/ps.6762. Epub 2022 Jan 24. PMID: 34927349. 13: Li Y, Wang Y, Li X, Fan H, Gao X, Peng Q, Li F, Lu L, Miao J, Liu X. Resistant risk and resistance-related point mutation in SdhC1 of pydiflumetofen in Fusarium pseudograminearum. Pest Manag Sci. 2023 Nov;79(11):4197-4207. doi: 10.1002/ps.7616. Epub 2023 Jun 30. PMID: 37326415. 14: Liu C, Shao W, Duan Y, Zhao Y, Liu Z, Ma Z. Biological and molecular characterization of pydiflumetofen and phenamacril dual-resistant Fusarium graminearum strains. Pest Manag Sci. 2024 Oct;80(10):4959-4966. doi: 10.1002/ps.8226. Epub 2024 Jun 6. PMID: 38843449. 15: Bian C, Gao M, Liu L, Zhou W, Li Y, Wan C, Li B. Determination of Pydiflumetofen Residues in Rice and its Environment by an Optimized QuEChERS Method Coupled with HPLC-MS. Bull Environ Contam Toxicol. 2021 Aug;107(2):239-247. doi: 10.1007/s00128-021-03282-9. Epub 2021 Jun 8. PMID: 34100970. 16: Shao W, Wang J, Wang H, Wen Z, Liu C, Zhang Y, Zhao Y, Ma Z. Fusarium graminearum FgSdhC1 point mutation A78V confers resistance to the succinate dehydrogenase inhibitor pydiflumetofen. Pest Manag Sci. 2022 May;78(5):1780-1788. doi: 10.1002/ps.6795. Epub 2022 Jan 31. PMID: 35014167. 17: Wang Z, Tan Y, Li Y, Duan J, Wu Q, Li R, Shi H, Wang M. Comprehensive study of pydiflumetofen in Danio rerio: Enantioselective insight into the toxic mechanism and fate. Environ Int. 2022 Sep;167:107406. doi: 10.1016/j.envint.2022.107406. Epub 2022 Jul 11. PMID: 35850082. 18: Liu S, Ma J, Jiang B, Yang G, Guo M. Functional characterization of MoSdhB in conferring resistance to pydiflumetofen in blast fungus Magnaporthe oryzae. Pest Manag Sci. 2022 Oct;78(10):4018-4027. doi: 10.1002/ps.7020. Epub 2022 Jun 17. PMID: 35645253. 19: Yin X, Gao X, Shen X, Ren F, Li Y, Zhou M, Zhang J, Duan Y. Resistance risk and mechanism of Ustilaginoidea virens to pydiflumetofen. Pestic Biochem Physiol. 2024 Dec;206:106200. doi: 10.1016/j.pestbp.2024.106200. Epub 2024 Oct 30. PMID: 39672629. 20: Wang Z, Li R, Zhang J, Liu S, He Z, Wang M. Evaluation of exploitive potential for higher bioactivity and lower residue risk enantiomer of chiral fungicide pydiflumetofen. 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