MedKoo Cat#: 461549 | Name: Rubraxanthone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Rubraxanthone is a compound isolated from Garcinia parvifolia Miq. that acts as a PAF inhibitor.

Chemical Structure

Rubraxanthone
Rubraxanthone
CAS#65411-01-0

Theoretical Analysis

MedKoo Cat#: 461549

Name: Rubraxanthone

CAS#: 65411-01-0

Chemical Formula: C24H26O6

Exact Mass: 410.1729

Molecular Weight: 410.46

Elemental Analysis: C, 70.23; H, 6.38; O, 23.39

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Rubraxanthone; Rubra-xanthone;
IUPAC/Chemical Name
(Z)-1-(3,7-dimethylocta-2,6-dien-1-yl)-3,6,8-trihydroxy-2-methoxy-9H-xanthen-9-one
InChi Key
JLTSTSRANGPLOQ-ZSOIEALJSA-N
InChi Code
InChI=1S/C24H26O6/c1-13(2)6-5-7-14(3)8-9-16-21-20(12-18(27)24(16)29-4)30-19-11-15(25)10-17(26)22(19)23(21)28/h6,8,10-12,25-27H,5,7,9H2,1-4H3/b14-8-
SMILES Code
O=C1C2=C(OC3=C1C(O)=CC(O)=C3)C=C(O)C(OC)=C2C/C=C(C)\CC/C=C(C)/C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 410.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Mohamed GA, Ibrahim SR, Shaaban MI, Ross SA. Mangostanaxanthones I and II, new xanthones from the pericarp of Garcinia mangostana. Fitoterapia. 2014 Oct;98:215-21. doi: 10.1016/j.fitote.2014.08.014. Epub 2014 Aug 13. PubMed PMID: 25128900. 2: Jantan I, Pisar MM, Idris MS, Taher M, Ali RM. In vitro inhibitory effect of rubraxanthone isolated from Garcinia parvifolia on platelet-activating factor receptor binding. Planta Med. 2002 Dec;68(12):1133-4. PubMed PMID: 12494345. 3: Wahyuni FS, Shaari K, Stanslas J, Lajis NH, Hamidi D. Cytotoxic Properties and Complete Nuclear Magnetic Resonance Assignment of Isolated Xanthones from the Root of Garcinia cowa Roxb. Pharmacogn Mag. 2016 Jan;12(Suppl 1):S52-6. doi: 10.4103/0973-1296.176115. PubMed PMID: 27041859; PubMed Central PMCID: PMC4792000. 4: Trinh DH, Ha LD, Tran PT, Nguyen LH. Isoprenylated xanthone and benzophenone constituents of the pericarp of Garcinia planchonii. Nat Prod Commun. 2014 Dec;9(12):1737-40. PubMed PMID: 25632472. 5: Azebaze AG, Teinkela JE, Nguemfo EL, Valentin A, Dongmo AB, Vardamides JC. Antiplasmodial activity of some phenolic compounds from Cameroonians Allanblackia. Afr Health Sci. 2015 Sep;15(3):835-40. doi: 10.4314/ahs.v15i3.18. PubMed PMID: 26957972; PubMed Central PMCID: PMC4765459. 6: Iinuma M, Tosa H, Tanaka T, Asai F, Kobayashi Y, Shimano R, Miyauchi K. Antibacterial activity of xanthones from guttiferaeous plants against methicillin-resistant Staphylococcus aureus. J Pharm Pharmacol. 1996 Aug;48(8):861-5. PubMed PMID: 8887739. 7: Ha LD, Hansen PE, Vang O, Duus F, Pham HD, Nguyen LH. Cytotoxic geranylated xanthones and O-alkylated derivatives of alpha-mangostin. Chem Pharm Bull (Tokyo). 2009 Aug;57(8):830-4. PubMed PMID: 19652408. 8: Kijjoa A, Gonzalez MJ, Pinto MM, Nascimento MS, Campos N, Mondranondra IO, Silva AM, Eaton G, Herz W. Cytotoxicity of prenylated xanthones and other constituents from the wood of Garcinia merguensis. Planta Med. 2008 Jun;74(8):864-6. doi: 10.1055/s-2008-1074544. Epub 2008 Jun 3. PubMed PMID: 18523924. 9: Ee GC, Foo CH, Jong VY, Ismail NH, Sukari MA, Taufiq Yap YH, Awang K. A new xanthone from Garcinia nitida. Nat Prod Res. 2012;26(9):830-5. doi: 10.1080/14786419.2011.559640. Epub 2011 Nov 1. PubMed PMID: 22044165. 10: Hamidi D, Aulia H, Susanti M. High Performance Thin layer Chromatography: Densitometry Method for Determination of Rubraxanthone in the Stem Bark Extract of Garcinia cowa Roxb. Pharmacognosy Res. 2017 Jul-Sep;9(3):230-233. doi: 10.4103/pr.pr_144_16. PubMed PMID: 28827962; PubMed Central PMCID: PMC5541477. 11: Azebaze AG, Meyer M, Bodo B, Nkengfack AE. Allanxanthone B, a polyisoprenylated xanthone from the stem bark of Allanblackia monticola Staner L.C. Phytochemistry. 2004 Sep;65(18):2561-4. PubMed PMID: 15451317. 12: Azebaze AG, Meyer M, Valentin A, Nguemfo EL, Fomum ZT, Nkengfack AE. Prenylated xanthone derivatives with antiplasmodial activity from Allanblackia monticola STANER L.C. Chem Pharm Bull (Tokyo). 2006 Jan;54(1):111-3. PubMed PMID: 16394561. 13: Trinh BT, Quach TT, Bui DN, Staerk D, Nguyen LD, Jäger AK. Xanthones from the twigs of Garcinia oblongifolia and their antidiabetic activity. Fitoterapia. 2017 Apr;118:126-131. doi: 10.1016/j.fitote.2017.03.003. Epub 2017 Mar 16. PubMed PMID: 28322990. 14: Abdallah HM, El-Bassossy HM, Mohamed GA, El-Halawany AM, Alshali KZ, Banjar ZM. Mangostanaxanthones III and IV: advanced glycation end-product inhibitors from the pericarp of Garcinia mangostana. J Nat Med. 2017 Jan;71(1):216-226. doi: 10.1007/s11418-016-1051-8. Epub 2016 Oct 13. PubMed PMID: 27738860. 15: Ibrahim SRM, Abdallah HM, El-Halawany AM, Nafady AM, Mohamed GA. Mangostanaxanthone VIII, a new xanthone from Garcinia mangostana and its cytotoxic activity. Nat Prod Res. 2018 Mar 7:1-8. doi: 10.1080/14786419.2018.1446012. [Epub ahead of print] PubMed PMID: 29513040.