MedKoo Cat#: 146002 | Name: KMD-3293

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KDM-3293 is a selective inhibitor of lysine-specific demethylase 1 (KDM1), an enzyme involved in the demethylation of histone proteins and the regulation of gene expression. By inhibiting KDM1, KDM-3293 affects the epigenetic regulation of genes, potentially reversing aberrant gene silencing or activation seen in various diseases. Its mechanism includes altering gene expression patterns involved in cell differentiation and proliferation. KDM-3293 is being explored for its therapeutic potential in treating cancers and other disorders associated with epigenetic modifications, such as neurodegenerative diseases.

Chemical Structure

KMD-3293
KMD-3293
CAS#1357252-79-9

Theoretical Analysis

MedKoo Cat#: 146002

Name: KMD-3293

CAS#: 1357252-79-9

Chemical Formula: C25H28F3N3O5

Exact Mass: 507.2000

Molecular Weight: 507.51

Elemental Analysis: C, 59.17; H, 5.56; F, 11.23; N, 8.28; O, 15.76

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
KMD-3293; KMD3293; KMD 3293;
IUPAC/Chemical Name
(R)-3-(7-carbamoyl-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indolin-1-yl)propanoic acid
InChi Key
VIWKOELUJFEJEQ-MRXNPFEDSA-N
InChi Code
1S/C25H30F3N3O5/c1-16(30-8-11-35-20-4-2-3-5-21(20)36-15-25(26,27)28)12-17-13-18-6-9-31(10-7-22(32)33)23(18)19(14-17)24(29)34/h2-5,13-14,16,30H,6-12,15H2,1H3,(H2,29,34)(H,32,33)/t16-/m1/s1
SMILES Code
C[C@H](CC1=CC(C(N)=O)=C2N(CCC(O)=O)CCC2=C1)NCCOC3=CC=CC=C3OCC(F)(F)F
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 507.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Shah PA, Shrivastav PS. Novel LC-MS/MS method for the quantification of silodosin and its metabolites in human plasma. Bioanalysis. 2018 Jan;10(1):7-10. doi: 10.4155/bio-2017-0242. Epub 2017 Dec 13. PMID: 29236515.