MedKoo Cat#: 128568 | Name: Tie2/VEGFR2 Kinase-IN-2
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tie2/VEGFR2 kinase-IN-2 is an inhibitor of tunica interna endothelial cell kinase 2 (Tie2) and VEGFR2 (IC50s = 13.49 and 7.76 nM, respectively).

Chemical Structure

Tie2/VEGFR2 Kinase-IN-2
Tie2/VEGFR2 Kinase-IN-2
CAS#501693-48-7

Theoretical Analysis

MedKoo Cat#: 128568

Name: Tie2/VEGFR2 Kinase-IN-2

CAS#: 501693-48-7

Chemical Formula: C20H13F4N5O2

Exact Mass: 431.1005

Molecular Weight: 431.35

Elemental Analysis: C, 55.69; H, 3.04; F, 17.62; N, 16.24; O, 7.42

Price and Availability

Size Price Availability Quantity
5mg USD 450.00 2 Weeks
10mg USD 750.00 2 Weeks
25mg USD 1,250.00 2 Weeks
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Related CAS #
No Data
Synonym
Tie2/VEGFR2 Kinase-IN-2; Tie2/VEGFR2 Kinase Inhibitor 2; Tie2/Vascular Endothelial Growth Factor Receptor 2 Kinase-IN-2
IUPAC/Chemical Name
1-(4-(4-aminofuro[2,3-d]pyrimidin-5-yl)phenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea
InChi Key
KNDPXYAMINMLED-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H13F4N5O2/c21-14-6-3-11(20(22,23)24)7-15(14)29-19(30)28-12-4-1-10(2-5-12)13-8-31-18-16(13)17(25)26-9-27-18/h1-9H,(H2,25,26,27)(H2,28,29,30)
SMILES Code
O=C(NC1=CC=C(C2=COC3=NC=NC(N)=C32)C=C1)NC4=C(F)C=CC(C(F)(F)F)=C4
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 431.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL