MedKoo Cat#: 145956 | Name: GW-856464

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GW-856464 is a selective herbicide used in agriculture to control a wide range of weeds, particularly in crops such as cereals and soybeans. It works by inhibiting the enzyme acetolactate synthase (ALS), which plays a critical role in the synthesis of branched-chain amino acids, essential for plant growth. By disrupting protein production in weeds, GW-856464 effectively stunts their growth and leads to weed death. This herbicide is applied to enhance crop yields by reducing weed competition and ensuring better access to resources like water, nutrients, and light for the crops.

Chemical Structure

GW-856464
GW-856464
CAS#851690-21-6

Theoretical Analysis

MedKoo Cat#: 145956

Name: GW-856464

CAS#: 851690-21-6

Chemical Formula: C23H20ClN3O3S

Exact Mass: 453.0900

Molecular Weight: 453.94

Elemental Analysis: C, 60.86; H, 4.44; Cl, 7.81; N, 9.26; O, 10.57; S, 7.06

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
GW-856464; GW856464; GW 856464;
IUPAC/Chemical Name
(R)-6-(4-chlorophenyl)-3-(4-(3-hydroxypyrrolidin-1-yl)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one
InChi Key
JOAYEJZDGOLEDZ-QGZVFWFLSA-N
InChi Code
1S/C23H20ClN3O3S/c1-30-20-10-16(6-7-19(20)26-9-8-17(28)12-26)27-13-25-18-11-21(31-22(18)23(27)29)14-2-4-15(24)5-3-14/h2-7,10-11,13,17,28H,8-9,12H2,1H3/t17-/m1/s1
SMILES Code
COC1=C(C=CC(=C1)N2C=NC3=C(SC(=C3)C4=CC=C(Cl)C=C4)C2=O)N5CC[C@@H](O)C5
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 453.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sariyer E, Sariyer AS. Computational prediction of analog compounds of the membrane protein MCHR1 antagonists ALB-127158 and KRX-104130. J Bioenerg Biomembr. 2023 Dec;55(6):435-446. doi: 10.1007/s10863-023-09993-4. Epub 2023 Nov 9. PMID: 37940722.