MedKoo Cat#: 145756 | Name: SCH-211803

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CH-211803 is a synthetic compound that has been investigated primarily for its potential as a selective antagonist of certain serotonin receptors, particularly the 5-HT3 receptor. This receptor is involved in processes like gastrointestinal motility and nausea. SCH-211803 has been studied in the context of antiemetic (anti-nausea) properties, particularly for its ability to reduce nausea and vomiting, which could make it useful in treating conditions like chemotherapy-induced nausea and vomiting (CINV).

Chemical Structure

SCH-211803
SCH-211803
CAS#331765-50-5

Theoretical Analysis

MedKoo Cat#: 145756

Name: SCH-211803

CAS#: 331765-50-5

Chemical Formula: C31H36ClN3O3S

Exact Mass: 565.2200

Molecular Weight: 566.16

Elemental Analysis: C, 65.77; H, 6.41; Cl, 6.26; N, 7.42; O, 8.48; S, 5.66

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
SCH-211803; SCH211803; SCH 211803;
IUPAC/Chemical Name
(2-amino-3-methylphenyl)(4-(4-((3-chlorophenyl)sulfonyl)benzyl)-[1,4'-bipiperidin]-1'-yl)methanone
InChi Key
VMJKUCKTXMESQR-UHFFFAOYSA-N
InChi Code
1S/C31H36ClN3O3S/c1-22-4-2-7-29(30(22)33)31(36)35-18-14-26(15-19-35)34-16-12-24(13-17-34)20-23-8-10-27(11-9-23)39(37,38)28-6-3-5-25(32)21-28/h2-11,21,24,26H,12-20,33H2,1H3
SMILES Code
CC1=CC=CC(C(=O)N2CCC(CC2)N3CCC(CC4=CC=C(C=C4)S(=O)(=O)C5=CC(Cl)=CC=C5)CC3)=C1N
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 566.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chen J, Yang L, Kapron JT, Ma L, Pace E, Van Pelt CK, Rudewicz PJ. Determination of SCH 211803 by nanoelectrospray infusion mass spectrometry: evaluation of matrix effect and comparison with liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Oct 5;809(2):205-10. doi: 10.1016/j.jchromb.2004.06.005. PMID: 15315766. 2: Yang L, Wu N, Clement RP, Rudewicz PJ. Validation and application of a liquid chromatography-tandem mass spectrometric method for the determination of SCH 211803 in rat and monkey plasma using automated 96-well protein precipitation. J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Jan 25;799(2):271-80. doi: 10.1016/j.jchromb.2003.10.058. PMID: 14670746. 3: Wang Y, Chackalamannil S, Hu Z, McKittrick BA, Greenlee W, Ruperto V, Duffy RA, Lachowicz JE. Sulfide analogues as potent and selective M(2) muscarinic receptor antagonists. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1087-91. doi: 10.1016/s0960-894x(02)00096-3. PMID: 11909724.