Bakuchicin | CAS#4412-93-5 | biochemical

MedKoo Cat#: 145744 | Name: Bakuchicin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Bakuchiol is a plant-based compound derived from the Psoralea corylifolia plant, commonly known as Babchi. It is often referred to as a natural alternative to retinol, due to its similar anti-aging and skin-rejuvenating effects. Bakuchiol has antioxidant, anti-inflammatory, and antimicrobial properties, which help in reducing signs of aging like wrinkles, fine lines, and pigmentation, while being gentler on the skin compared to retinol. It's also known to enhance collagen production, improve skin texture, and can be used for sensitive skin without the irritation often caused by retinoids.

Chemical Structure

Bakuchicin

CAS#4412-93-5

Theoretical Analysis

MedKoo Cat#: 145744

Name: Bakuchicin

CAS#: 4412-93-5

Chemical Formula: C11H6O3

Exact Mass: 186.0300

Molecular Weight: 186.17

Elemental Analysis: C, 70.97; H, 3.25; O, 25.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Bakuchicin; Allopsoralen;

IUPAC/Chemical Name

7H-furo[2,3-f]chromen-7-one

InChi Key

HMUJHZNYHJMOHR-UHFFFAOYSA-N

InChi Code

1S/C11H6O3/c12-10-4-2-8-9(14-10)3-1-7-5-6-13-11(7)8/h1-6H

SMILES Code

O=C1OC2=CC=C3C=COC3=C2C=C1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 186.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Lim JS, Kim JY, Lee S, Choi JK, Kim EN, Choi YA, Jang YH, Jeong GS, Kim SH. Bakuchicin attenuates atopic skin inflammation. Biomed Pharmacother. 2020 Sep;129:110466. doi: 10.1016/j.biopha.2020.110466. Epub 2020 Jul 1. PMID: 32768955. 2: Kim YY, Jeong S, Lee SW, Lee SJ, Rho MC, Kim SH, Lee S. Bakuchicin alleviates ovalbumin-induced allergic asthma by regulating M2 macrophage polarization. Inflamm Res. 2024 May;73(5):725-737. doi: 10.1007/s00011-024-01859-8. Epub 2024 Mar 27. PMID: 38538755. 3: Li X, Lee YJ, Kim YC, Jeong GS, Cui HZ, Kim HY, Kang DG, Lee HS. Bakuchicin induces vascular relaxation via endothelium-dependent NO-cGMP signaling. Phytother Res. 2011 Oct;25(10):1574-8. doi: 10.1002/ptr.3478. Epub 2011 Mar 28. PMID: 21442677. 4: Kim SJ, Oh HC, Kim YC, Jeong GS, Lee S. Selective Inhibition of Bakuchicin Isolated from Psoralea corylifolia on CYP1A in Human Liver Microsomes. Evid Based Complement Alternat Med. 2016;2016:5198743. doi: 10.1155/2016/5198743. Epub 2016 Feb 9. PMID: 26977174; PMCID: PMC4763008. 5: Jo JH, Kim JH, Lee HS, Jeong GS, Lee JM, Lee S. Investigation of pharmacokinetic parameters of bakuchicin isolated from Psoralea corylifolia in mice. Fitoterapia. 2017 Jul;120:194-198. doi: 10.1016/j.fitote.2017.06.007. Epub 2017 Jun 8. PMID: 28602940. 6: Liao ZC, Jiang X, Tian WJ, Lin T, Chen HF. [Chemical constituents from root of Angelica decursiva]. Zhongguo Zhong Yao Za Zhi. 2017 Aug;42(15):2999-3003. Chinese. doi: 10.19540/j.cnki.cjcmm.20170512.003. PMID: 29139270. 7: Baek SC, Kang MG, Park JE, Lee JP, Lee H, Ryu HW, Park CM, Park D, Cho ML, Oh SR, Kim H. Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity. Bioorg Med Chem Lett. 2019 Mar 15;29(6):839-843. doi: 10.1016/j.bmcl.2019.01.016. Epub 2019 Jan 18. PMID: 30686752. 8: Tao Y, Pu J, Wang P. Ethnobotany, phytochemistry, pharmacology and quality control of Peucedanum decursivum (Miq.) Maxim: A critical review. J Ethnopharmacol. 2024 Nov 15;334:118542. doi: 10.1016/j.jep.2024.118542. Epub 2024 Jul 9. PMID: 38992404. 9: Sun NJ, Woo SH, Cassady JM, Snapka RM. DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia. J Nat Prod. 1998 Mar;61(3):362-6. doi: 10.1021/np970488q. Erratum in: J Nat Prod. 2003 May;66(5):734. PMID: 9544566. 10: Cho H, Jun JY, Song EK, Kang KH, Baek HY, Ko YS, Kim YC. Bakuchiol: a hepatoprotective compound of Psoralea corylifolia on tacrine-induced cytotoxicity in Hep G2 cells. Planta Med. 2001 Nov;67(8):750-1. doi: 10.1055/s-2001-18347. PMID: 11731920. 11: Khatune NA, Islam ME, Haque ME, Khondkar P, Rahman MM. Antibacterial compounds from the seeds of Psoralea corylifolia. Fitoterapia. 2004 Mar;75(2):228-30. doi: 10.1016/j.fitote.2003.12.018. PMID: 15030932.