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MedKoo Cat#: 128312 | Name: (R)-ZG197

Description:

WARNING: This product is for research use only, not for human or veterinary use.

(R)-ZG197 is a selective ClpP agonist.

Chemical Structure

(R)-ZG197
(R)-ZG197
CAS#2999672-72-7

Theoretical Analysis

MedKoo Cat#: 128312

Name: (R)-ZG197

CAS#: 2999672-72-7

Chemical Formula: C28H35F3N4O3

Exact Mass: 532.2661

Molecular Weight: 532.61

Elemental Analysis: C, 63.14; H, 6.62; F, 10.70; N, 10.52; O, 9.01

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
(R)-ZG197; (R)ZG197; (R) ZG197
IUPAC/Chemical Name
(6S,9aS)-6-((S)-sec-butyl)-8-((R)-1-(naphthalen-1-yl)ethyl)-4,7-dioxo-N-(4,4,4-trifluorobutyl)hexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide
InChi Key
BAZGDIOJCKGDHH-RHDWJPPYSA-N
InChi Code
InChI=1S/C28H35F3N4O3/c1-4-18(2)25-26(37)34(19(3)21-12-7-10-20-9-5-6-11-22(20)21)17-23-33(16-13-24(36)35(23)25)27(38)32-15-8-14-28(29,30)31/h5-7,9-12,18-19,23,25H,4,8,13-17H2,1-3H3,(H,32,38)/t18-,19+,23+,25-/m0/s1
SMILES Code
FC(F)(F)CCCNC(N1[C@](CN([C@H](C)C2=CC=CC3=C2C=CC=C3)C([C@@H]4[C@@H](C)CC)=O)([H])N4C(CC1)=O)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 532.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Wei B, Zhang T, Wang P, Pan Y, Li J, Chen W, Zhang M, Ji Q, Wu W, Lan L, Gan J, Yang CG. Anti-infective therapy using species-specific activators of Staphylococcus aureus ClpP. Nat Commun. 2022 Nov 14;13(1):6909. doi: 10.1038/s41467-022-34753-0. PMID: 36376309; PMCID: PMC9663597. 2. Zhang T, Wu W, Zhao Y, Ding Z, Wei B, Yang T, Li J, Wang P, Lan L, Gan J, Yang CG. Structure-Guided Development of ClpP Agonists with Potent Therapeutic Activities against Staphylococcus aureus Infection. J Med Chem. 2025 Jan 6. doi: 10.1021/acs.jmedchem.4c02562. Epub ahead of print. PMID: 39760203.