Synonym
Halofantrine hydrochloride; Halfan; Halofantrine HCl; Halofantrino [Spanish]; WR 171669; WR-171,669; WR-171699; halofantrine;
IUPAC/Chemical Name
3-(dibutylamino)-1-[1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl]propan-1-ol;hydrochloride
InChi Key
WANGFTDWOFGECH-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H30Cl2F3NO.ClH/c1-3-5-10-32(11-6-4-2)12-9-25(33)23-16-22-21(14-18(27)15-24(22)28)20-13-17(26(29,30)31)7-8-19(20)23;/h7-8,13-16,25,33H,3-6,9-12H2,1-2H3;1H
SMILES Code
CCCCN(CCCC)CCC(C1=C2C=CC(=CC2=C3C=C(C=C(C3=C1)Cl)Cl)C(F)(F)F)O.Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
comments |
| Solubility |
| Soluble in DMSO, not in water |
0.0 |
0.00 |
|
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
536.88
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Khoo SM, Prankerd RJ, Edwards GA, Porter CJ, Charman WN. A physicochemical basis for the extensive intestinal lymphatic transport of a poorly lipid soluble antimalarial, halofantrine hydrochloride, after postprandial administration to dogs. J Pharm Sci. 2002 Mar;91(3):647-59. PubMed PMID: 11920750.
2: Del Nero L, Lamizana L, Nebie I, Sare S, Bougouma L, Pietra V. In vivo sensitivity of Plasmodium falciparum to halofantrine hydrochloride in Burkina Faso. Am J Trop Med Hyg. 1994 Jan;50(1):102-6. PubMed PMID: 8304564.
3: Gillespie SH, Msaki EP, Ramsay A, Ngowi FI, Fox R. A new micronized formulation of halofantrine hydrochloride in the treatment of acute Plasmodium falciparum malaria. Trans R Soc Trop Med Hyg. 1993 Jul-Aug;87(4):467-9. PubMed PMID: 8249083.
4: Khan MA, Rehman GN, Qazi SA. Halofantrine hydrochloride--efficacy and safety in children with acute malaria. J Pak Med Assoc. 1991 Jan;41(1):8-10. PubMed PMID: 1900550.
