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MedKoo Cat#: 128295 | Name: GSK-3β inhibitor 1
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSK-3β inhibitor 1 (compound 3a) is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy, with an IC50 of 4.9 nM.

Chemical Structure

GSK-3β inhibitor 1
GSK-3β inhibitor 1
CAS#187325-53-7

Theoretical Analysis

MedKoo Cat#: 128295

Name: GSK-3β inhibitor 1

CAS#: 187325-53-7

Chemical Formula: C14H10N2O

Exact Mass: 222.0793

Molecular Weight: 222.25

Elemental Analysis: C, 75.66; H, 4.54; N, 12.60; O, 7.20

Price and Availability

Size Price Availability Quantity
5mg USD 450.00 2 Weeks
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Related CAS #
No Data
Synonym
GSK-3β inhibitor 1; GSK 3β inhibitor 1
IUPAC/Chemical Name
(Z)-3-(pyridin-2-ylmethylene)indolin-2-one
InChi Key
YKQONSWBHGBDSB-XFXZXTDPSA-N
InChi Code
InChI=1S/C14H10N2O/c17-14-12(9-10-5-3-4-8-15-10)11-6-1-2-7-13(11)16-14/h1-9H,(H,16,17)/b12-9-
SMILES Code
O=C1NC2=CC=CC=C2/C1=C/C3=NC=CC=C3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 222.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lee JK, Chatterjee A, Scarpa M, Bailey CM, Niyongere S, Singh P, Mustafa Ali MK, Kapoor S, Wang Y, Silvestri G, Baer MR. Pim Kinase Inhibitors Increase Gilteritinib Cytotoxicity in FLT3-ITD Acute Myeloid Leukemia Through GSK-3β Activation and c-Myc and Mcl-1 Proteasomal Degradation. Cancer Res Commun. 2024 Feb 16;4(2):431-445. doi: 10.1158/2767-9764.CRC-23-0379. PMID: 38284896; PMCID: PMC10870818. 2: Zhao Y, He C, Hu S, Ni H, Tan X, Zhi Y, Yi L, Na R, Li Y, Du Q, Li QX, Dong Y. Anti-oxidative stress and cognitive improvement of a semi-synthetic isoorientin-based GSK-3β inhibitor in rat pheochromocytoma cell PC12 and scopolamine-induced AD model mice via AKT/GSK-3β/Nrf2 pathway. Exp Neurol. 2024 Oct;380:114881. doi: 10.1016/j.expneurol.2024.114881. Epub 2024 Jul 10. PMID: 38996864. 3: Scarpa M, Singh P, Bailey CM, Lee JK, Kapoor S, Lapidus RG, Niyongere S, Sangodkar J, Wang Y, Perrotti D, Narla G, Baer MR. PP2A-activating Drugs Enhance FLT3 Inhibitor Efficacy through AKT Inhibition-Dependent GSK-3β-Mediated c-Myc and Pim-1 Proteasomal Degradation. Mol Cancer Ther. 2021 Apr;20(4):676-690. doi: 10.1158/1535-7163.MCT-20-0663. Epub 2021 Feb 10. PMID: 33568357; PMCID: PMC8027945. 4: Mudireddy SR, Abdul AR, Gorjala P, Gary RK. Beryllium is an inhibitor of cellular GSK-3β that is 1,000-fold more potent than lithium. Biometals. 2014 Dec;27(6):1203-16. doi: 10.1007/s10534-014-9783-y. Epub 2014 Aug 8. PMID: 25104312. 5: Rampa A, Gobbi S, Concetta Di Martino RM, Belluti F, Bisi A. Dual BACE-1/GSK-3β Inhibitors to Combat Alzheimer's Disease: A Focused Review. Curr Top Med Chem. 2017;17(31):3361-3369. doi: 10.2174/1568026618666180112161406. PMID: 29332582. 6: Góral I, Wichur T, Sługocka E, Godyń J, Szałaj N, Zaręba P, Głuch-Lutwin M, Mordyl B, Panek D, Więckowska A. Connecting GSK-3β Inhibitory Activity with IKK-β or ROCK-1 Inhibition to Target Tau Aggregation and Neuroinflammation in Alzheimer's Disease-Discovery, In Vitro and In Cellulo Activity of Thiazole- Based Inhibitors. Molecules. 2024 Jun 2;29(11):2616. doi: 10.3390/molecules29112616. PMID: 38893493; PMCID: PMC11173485. 7: Gao L, Gao S, Shan H, Wu Y, Zhou Q. GSK-3β inhibitor TWS119 promotes neuronal differentiation after hypoxic-ischemic brain damage in neonatal rats. Neuroreport. 2024 Feb 7;35(3):200-207. doi: 10.1097/WNR.0000000000002006. Epub 2024 Jan 31. PMID: 38305107; PMCID: PMC10833190. 8: Soni D, Kumar P. GSK-3β-mediated regulation of Nrf2/HO-1 signaling as a new therapeutic approach in the treatment of movement disorders. Pharmacol Rep. 2022 Aug;74(4):557-569. doi: 10.1007/s43440-022-00390-z. Epub 2022 Jul 26. PMID: 35882765. 9: Zhong J, Yu X, Zhong Y, Tan L, Yang F, Xu J, Wu J, Lin Z. GSK-3β inhibitor amplifies autophagy-lysosomal pathways by regulating TFEB in Parkinson's disease models. Exp Neurol. 2025 Jan;383:115033. doi: 10.1016/j.expneurol.2024.115033. Epub 2024 Oct 26. PMID: 39490621. 10: Xie Y, Chen C, Lin S, Yu X, Ye S, Chen X, Ouyang N, Xiong W, Li C, Xu C, Song G, Wu H. Design, synthesis and anti-AD effects of dual inhibitor targeting glutaminyl cyclase/GSK-3β. Eur J Med Chem. 2023 Feb 15;248:115089. doi: 10.1016/j.ejmech.2023.115089. Epub 2023 Jan 6. PMID: 36638710.

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