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MedKoo Cat#: 128271 | Name: EP-80317

Description:

WARNING: This product is for research use only, not for human or veterinary use.

EP-80317 is a CD36 inhibitor.

Chemical Structure

EP-80317
EP-80317
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128271

Name: EP-80317

CAS#: N/A

Chemical Formula: C57H70N12O7

Exact Mass: 1034.5490

Molecular Weight: 1035.26

Elemental Analysis: C, 66.13; H, 6.82; N, 16.24; O, 10.82

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
EP-80317; EP80317; EP 80317
IUPAC/Chemical Name
(3S,6S)-N-((2R,5R,8S,11R,14S)-8-((1H-indol-3-yl)methyl)-18-amino-5-(4-aminobutyl)-11-benzyl-14-carbamoyl-1-(2-methyl-1H-indol-3-yl)-3,6,9,12-tetraoxo-4,7,10,13-tetraazaoctadecan-2-yl)-3-amino-4-oxo-1,2,3,4,6,7-hexahydroazepino[3,2,1-hi]indole-6-carboxamide
InChi Key
BXISKCFZKFDZBJ-RWKPYQOYSA-N
InChi Code
InChI=1S/C57H70N12O7/c1-33-40(39-19-6-8-21-43(39)63-33)31-48(68-56(75)49-30-36-17-13-16-35-24-25-41(60)57(76)69(49)50(35)36)55(74)65-45(23-10-12-27-59)52(71)67-47(29-37-32-62-42-20-7-5-18-38(37)42)54(73)66-46(28-34-14-3-2-4-15-34)53(72)64-44(51(61)70)22-9-11-26-58/h2-8,13-21,32,41,44-49,62-63H,9-12,22-31,58-60H2,1H3,(H2,61,70)(H,64,72)(H,65,74)(H,66,73)(H,67,71)(H,68,75)/t41-,44-,45+,46+,47-,48+,49-/m0/s1
SMILES Code
NC([C@@H](NC([C@H](NC([C@@H](NC([C@H](NC([C@H](NC([C@H]1N(C([C@@H](N)CC2)=O)C(C2=CC=C3)=C3C1)=O)CC4=C(C)NC5=C4C=CC=C5)=O)CCCCN)=O)CC6=CNC7=C6C=CC=C7)=O)CC8=CC=CC=C8)=O)CCCCN)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,035.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bujold K, Mellal K, Zoccal KF, Rhainds D, Brissette L, Febbraio M, Marleau S, Ong H. EP 80317, a CD36 selective ligand, promotes reverse cholesterol transport in apolipoprotein E-deficient mice. Atherosclerosis. 2013 Aug;229(2):408-14. doi: 10.1016/j.atherosclerosis.2013.05.031. Epub 2013 Jun 14. PMID: 23880196. 2: Bessi VL, Labbé SM, Huynh DN, Ménard L, Jossart C, Febbraio M, Guérin B, Bentourkia M, Lecomte R, Carpentier AC, Ong H, Marleau S. EP 80317, a selective CD36 ligand, shows cardioprotective effects against post-ischaemic myocardial damage in mice. Cardiovasc Res. 2012 Oct 1;96(1):99-108. doi: 10.1093/cvr/cvs225. Epub 2012 Jul 10. PMID: 22787133. 3: Lucchi C, Costa AM, Giordano C, Curia G, Piat M, Leo G, Vinet J, Brunel L, Fehrentz JA, Martinez J, Torsello A, Biagini G. Involvement of PPARγ in the Anticonvulsant Activity of EP-80317, a Ghrelin Receptor Antagonist. Front Pharmacol. 2017 Sep 22;8:676. doi: 10.3389/fphar.2017.00676. PMID: 29018345; PMCID: PMC5614981. 4: Elimam H, Gauvin J, Huynh DN, Ménard L, Al-Hawat ML, Harb D, Lubell WD, Carpentier AC, Ong H, Marleau S. Targeting CD36 With EP 80317 Reduces Remote Inflammatory Response to Hind Limb Ischemia-Reperfusion in Mice. J Biochem Mol Toxicol. 2024 Dec;38(12):e70057. doi: 10.1002/jbt.70057. PMID: 39552437; PMCID: PMC11582942. 5: Marleau S, Harb D, Bujold K, Avallone R, Iken K, Wang Y, Demers A, Sirois MG, Febbraio M, Silverstein RL, Tremblay A, Ong H. EP 80317, a ligand of the CD36 scavenger receptor, protects apolipoprotein E-deficient mice from developing atherosclerotic lesions. FASEB J. 2005 Nov;19(13):1869-71. doi: 10.1096/fj.04-3253fje. Epub 2005 Aug 25. PMID: 16123174. 6: Biagini G, Torsello A, Marinelli C, Gualtieri F, Vezzali R, Coco S, Bresciani E, Locatelli V. Beneficial effects of desacyl-ghrelin, hexarelin and EP-80317 in models of status epilepticus. Eur J Pharmacol. 2011 Nov 16;670(1):130-6. doi: 10.1016/j.ejphar.2011.08.020. Epub 2011 Sep 2. PMID: 21914437.

View History

LSN3316612

LSN3316612